Observational Dutch Young Symptomatic StrokE studY - Extended

Recruiting

Conditions: cerebrovascular accident
Stroke
10011082
10007963
10003216

Registration Number: NL-OMON54052

Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 260

Inclusion Criteria

Patients with a first-ever transient ischemic attack (TIA) or acute ischemic
stroke aged between 18 and 50 years old will be included. For this study, acute
stroke is defined as occurence of acute neurological deficit lasting more than
24 hours, with confirmation on imaging (CT(-a) or MR(-a)).TIA is defined as
occurence of acute neurological deficit lasting less than 24 hours with
confirmation of ischemia on MRI). Patients are able to provide informed consent
and a kidney function eGFR>30ml/min.

Exclusion Criteria

Main exclusion criteria are: history of clinical TIA, ischemic stroke or
intracerebral hemorrhage. A intracerebral hemorrhage resulting from trauma,
known aneurysm or underlying intracerebral malignancy. A venous infarction,
retinal infarction and amourosis fugax. Inadequate control of the Dutch
language to reliably sign an informed consent from and/or participate in the
follow-up. Patients are excluded if they have a contra indication for 3T MRI.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>What is the role of the immune system in the cause of a first-ever ischemic<br /><br>stroke or TIA before their 50th year?</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>• What is the role of triggerfactors on the immune system in patients with a<br />first-ever ischemic stroke or TIA before their 50th year?<br />• What is the role of the immune system on the vascular wall function in<br />patients with a first-ever ischemic stroke or TIA before their 50th year?<br />• What is the risk of long term complications in patients who suffer from an<br />ischemic stroke or TIA between their 18th and 50th year?<br />• What is the impact of a first-ever ischemic stroke or TIA before their 50th<br />year on the functional prognosis?<br />• What is the effect of coping strategies on cognitive and functional prognosis<br />in patients with a first-ever ischemic stroke or TIA before their 50th year?</p>