ACTRN12613000032752撤回4 期
Statin Therapy in Ischemia-Reperfusion Injury: A randomised trial to evaluate the effect of high dose rosuvastatin on myocardial infarct size post ST elevation myocardial infarction (STEMI).
适应症
试验速览
- 阶段
- 4 期
- 状态
- 撤回
- 发起方
- SAHMRI
- 入组人数
- 300
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
入排标准
- 年龄范围
- 18 Years 至 80 Years（—）
- 性别
- All
入选标准
- •Symptoms of acute myocardial infarction within 12 hours with ST elevation of more than 1 mm in at least two contigous leads on ECG of new onset Left Bundle Branch Block.
- •Provision of written informed consent.
排除标准
- •Cardiogenic shock or symptomatic hypotension or sitting SBP < 95 mm Hg
- •Previous MI
- •Standard CMR contraindications (e.g. pacemaker, severe claustrophobia etc.)
- •Known serious or hypersensitivity reactions to statin
- •known familial hypercholesterolemia
- •known active liver disease or significant renal failure (eGFR < 45 mls/min)
- •Non-cardiac comorbidity with life expectation < 1 year.
- •Patients who are Filipino, Chinese, Japanese, Korean or Vietnamese.
- •Patients taking any of the following cyclosporine, gemfibrozel or fusidic acid.
- •Attending consultant intends to use high dose statin therapy, Atorvastatin 80 mgs or Rosuvastatin 40 mgs.
研究者
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