Fear conditioning during specific conditions in antisocial adolescents: a neuroimaging study. - fear conditioning and fMRI in antisocial adolescents

Vrije Universiteit Medisch Centrum0 个研究点目标入组 83 人开始时间: 待定最近更新: 2024年6月11日

适应症

试验速览

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•DBD: Subject is diagnosed with ODD (oppositional defiant disorder) and/or CD (conduct disorder). The diagnosis will be confirmed by a standardized psychiatric interview (DISC).
•HC:IQ, SES and age similar to an adolescent in the basic condition. SES in the same category, IQ in a range of 5 points and age in a range of 1 month.

•DBD: Intraocular shreads of metal. Cardiac pacemaker, metal arterial clips, cochlear implant, implanted heart-valves, other implants or metal objects in the body (e.g. non-removable body piercings) not compatible with magnetic fields . Use of medication effecting brain functioning, except for methylphenidate that can be stopped during the day of scanning and the two days before. Pervasive developmental disorder, Tourette*s syndrome, current or lifetime history of psychosis, neurologic disorder, history of head trauma, actual steroid use an IQ less than 80.
•Contraindications for the use of Methylphenidate. (see protocol page 22)
•HC: Standard exclusion criteria (NIH) for MRI are the presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body. Contra-indications for using methylphenidate (see page 22). ODD, CD, ADHD, Pervasive developmental disorder, Tourette*s syndrome, current or lifetime history of psychosis, neurologic disorder, history of head trauma, actual steroid use an IQ less than 80. A history of serious antisocial behavior. Use of psychotropic medication

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