NCT07127510招募中不适用
Measurement of Brain NAD Levels in Alzheimer's Patients and Control Subjects by 1H-MRS
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Brain NAD
研究概览
简要总结
The goal of this observational study is to learn about the levels of nicotinamide adenine dinucleotide (NAD) in the brains of people with Alzheimer's disease. The study aims to determine if brain NAD levels are lower in people with Alzheimer's disease compared with people of the same age group who do not have Alzheimer's disease.
Participants with or without Alzheimer's disease will have a brain imaging session where NAD will be measured using magnetic resonance spectroscopy (MRS). Eight months later, they will have a second, similar, brain imaging session.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 65 Years 至 80 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants are able to come to the Florida Atlantic University Clinical Research Unit, are verbal and ambulatory.
- •Age 65 to 80 included.
- •People with Alzheimer's disease (AD): AD diagnosis established by the person's physician according to the following criteria: clinical diagnosis AND either positive amyloid PET-scan or FDA-approved positive CSF or blood test.
排除标准
- •Under the age of 65 or over the age of
- •Advanced dementia such that the person would require sedation for undergoing an MRI scan.
- •Receiving anti-amyloid intravenous treatments Leqembi or Kinsula.
- •Having an MRI-incompatible pacemaker or other MRI-incompatible hardware (e.g. comprising a metallic part).
- •Having a history of seizures.
- •Working at night.
- •Having cancer or having been diagnosed with cancer within the last 5 years (excluding superficial squameous or basal cell cancer).
- •People with no AD: MoCA test result lower than 26.
结局指标
主要结局
Brain NAD
时间窗: At enrollment and 8 months after enrollment
NAD levels measured by 1H-MRS
次要结局
未报告次要终点
研究者
Corinne Lasmezas
Professor
Florida Atlantic University
研究点 (1)
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