Sleep, Energy Metabolism and Diabetes Risk.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 2
- 主要终点
- Total body insulin sensitivity
研究概览
简要总结
The use of sugar and starch-like foods for energy (carbohydrate metabolism) changes when people sleep. However, it is still not known if differences in the amount of nighttime sleep have an effect on the carbohydrate metabolism of people who have a relative with type 2 diabetes (parent, sibling, or grandparent). This study is being done to test the hypothesis that the carbohydrate metabolism of people who have a history of type 2 diabetes in their family will be different after they have slept short hours for 10 days in comparison to when they have slept longer hours for 10 days.
详细描述
Study participants will complete two 10-day inpatient stays in the sleep laboratory of the University of Chicago Clinical Resource Center scheduled at least 4 weeks apart. Bedtime duration will be set at 5 hours per night during one of these stays and 8.5 hours per night during the other. No daytime naps will be allowed. Study participants will be served regular daily meals including breakfast, lunch, dinner, and a bedtime snack. On weekdays all participants will engage in simulated "office work" while in the sleep laboratory. During the rest of the time participants will maintain their usual indoor and outdoor activities as much as possible within the limits of the University of Chicago campus. During the last two days of each inpatient stay in the laboratory, participants will undergo two different tests. The first test will determine how much insulin does their body produce in response to an intravenous glucose infusion lasting several hours. The second test will determine how effective is the action of the sugar-processing hormone, insulin, in their body when it is infused intravenously together with glucose over a period of several hours.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •regular sleep habits
- •BMI 20 to 27 kg/m2
- •at least one parent, sibling or grandparent with type 2 diabetes
- •no regular exercise habits
排除标准
- •active smoker
- •night or shift work
- •have highly variable sleep habits
- •have a hormonal disorder
- •have a sleep disorder
- •have an active medical problem
- •women only: use of birth control pills
- •women only: irregular menstrual periods or pregnancy
- •use of medications/compounds that can disrupt sleep
结局指标
主要结局
Total body insulin sensitivity
时间窗: at the end of each bedtime intervention
次要结局
- First and second phase insulin secretion(at the end of each bedtime intervention)
- Endogenous glucose production(at the end of each bedtime intervention)
- Glycerol turnover and free fatty acid concentrations(at the end of each bedtime intervention)