Effects of Pre-operative Oral Pregabalin on Post Operative Morphine Consumption After Abdominal Hysterectomy With/Without Salpingo-oophorectomy Under Spinal Anesthesia With Intrathecal Morphine
Overview
- Phase
- Phase 4
- Intervention
- placebo
- Conditions
- Post Operative Pain
- Sponsor
- Mahidol University
- Enrollment
- 125
- Locations
- 1
- Primary Endpoint
- Post Operative Morphine Consumption
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
This study aims to compare the effect of pre-operative oral pregabalin on post operative morphine consumption after abdominal hysterectomy with/without salpingo-oophorectomy.
Detailed Description
The participants are randomized into two groups by computer randomization. The patient undergo spinal anesthesia with 0.5% Heavy bupivacaine with morphine 0.2 mg. IV PCA morphine is initiate in the post-anesthetic care unit. We compare post operative morphine consumption in the first 24 hours, time to first analgesia, adverse event, and patient satisfaction.
Investigators
Eligibility Criteria
Inclusion Criteria
- •ASA classification 1-2 undergoing abdominal hysterectomy with/without salpingo-oophorectomy under spinal anesthesia with intrathecal morphine
- •Patient can use patient-controlled analgesia (IV PCA)
Exclusion Criteria
- •History of drug allergy to gabapentinoid and related drug
- •History of regular analgesic drug use, psychiatric drug usage, drug abuse, alcohol addiction or chronic pain patient
- •Renal disease (Creatinine Clearance \< 60), Liver disease, Seizure disorder and Psychiatric disorder
Arms & Interventions
Placebo
Placebo in capsule is prescribed to the patient 60 min prior to the surgery.
Intervention: placebo
Pregabalin
Pregabalin (150 mg) one capsule is prescribed to the patient 60 min prior to the surgery.
Intervention: Pregabalin
Outcomes
Primary Outcomes
Post Operative Morphine Consumption
Time Frame: 6, 12, and 24 hours after operation
Cumulative morphine consumption in the first 24 hours is recorded from IV PCA
Secondary Outcomes
- Time to First Analgesia(24 hours)
- Pain Scores on the Visual Analog Scale(24 hours)
- Numbers of Participants With Adverse Events as a Measure of Safety and Tolerability(24 hours)
- Number of Patients Evaluating Their Satisfaction(24 hours)