NCT03211728
Completed
Not Applicable
Does Perioperative Pregabalin Reduce Postoperative Pain After Arthroscopic Anterior Cruciate Ligament Reconstruction Surgery Under Spinal Anesthesia?
Overview
- Phase
- Not Applicable
- Intervention
- pregabalin
- Conditions
- Anterior Cruciate Ligament (ACL) Reconstruction
- Sponsor
- Yonsei University
- Enrollment
- 96
- Locations
- 1
- Primary Endpoint
- Postoperative pain scores
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The investigators hypothesize that perioperative oral administration of pregabalin would reduce postoperative pain and produce reduction in postoperative opioid consumption after anterior cruciate ligament (ACL) reconstruction . Patients are randomly assign to 1 of 2 groups. The placebo group receive placebo capsules 1 hour before surgery and 12 hours after initial dose. The pregabalin group receive pregabalin 150 mg, respectively at the same points.
Investigators
Eligibility Criteria
Inclusion Criteria
- •age between 20-65 years
- •physical condition type I or II in ASA (American Society of Anesthesiology)
Exclusion Criteria
- •patients of ASA classification 3 or more
- •with a history of cardiovascular or respiratory disease
- •dizziness or frequent headache
- •active alcohol or drug usage,
- •intake of any analgesics daily or 48 hours before surgery
- •impaired renal and/or hepatic function
Arms & Interventions
experimental group
Intervention: pregabalin
placebo group
Intervention: placebo
Outcomes
Primary Outcomes
Postoperative pain scores
Time Frame: 2 weeks after surgery
Visual analog scale (VAS) score = 0-100 mm
Secondary Outcomes
- Opioid consumption(the first 48 hours after surgery)
Study Sites (1)
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