The Effects of Peri-operative Pregabalin Administration on Post-operative Analgesia in Patients Undergoing Coronary Bypass Grafting

Phase 3

• Conditions: Postoperative Pain.
• Interventions: Drug: Placebo/Lactose; Drug: Pregabalin

• Registration Number: NCT00623285
• Lead Sponsor: University of Manitoba

Brief Summary

We hypothesize that the perioperative administration of pregabalin will significantly decrease pain scores and post-operative opioid requirements for patients undergoing coronary artery bypass grafting, and reduces the incidence of opioid-induced side effects such as respiratory depression. This may reduce ICU admission and possibly abbreviate length of hospital stay.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2008-02-14
• Study First Submitted QC: 2008-02-14
• Study First Posted: 2008-02-26
• Study Start: 2008-04
• Status Verified: 2011-03
• Primary Completion: 2011-03
• Last Update Submitted: 2011-03-14
• Last Update Posted: 2011-03-16
• Study Completion: 2011-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group 2	Placebo/Lactose	-
Group 1	Pregabalin	-

Primary Outcome Measures

Name	Time	Method
Pain scores and morphine consumption post surgery	6 months

Secondary Outcome Measures

Name	Time	Method
To determine the occurrence of opioid-related side effects such as nausea, vomiting, and respiratory depression in patients receiving pregabalin compared to those receiving placebo.	6 days

Trial Locations

Locations (1)

St. Boniface General Hospital; 🇨🇦 Winnipeg, Manitoba, Canada