The Effects of Peri-operative Pregabalin Administration on Post-operative Analgesia in Patients Undergoing Coronary Bypass Grafting

University of Manitoba1 site in 1 country40 target enrollmentApril 2008

ConditionsPostoperative Pain.

InterventionsPregabalin Placebo/Lactose

DrugsPregabalin Placebo/Lactose

Overview

Phase: Phase 3
Intervention: Pregabalin
Conditions: Postoperative Pain.
Sponsor: University of Manitoba
Enrollment: 40
Locations: 1
Primary Endpoint: Pain scores and morphine consumption post surgery
Last Updated: 15 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

We hypothesize that the perioperative administration of pregabalin will significantly decrease pain scores and post-operative opioid requirements for patients undergoing coronary artery bypass grafting, and reduces the incidence of opioid-induced side effects such as respiratory depression. This may reduce ICU admission and possibly abbreviate length of hospital stay.

Registry

clinicaltrials.gov

Start Date

April 2008

End Date

June 2011

Last Updated

15 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University of Manitoba

Eligibility Criteria

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Arms & Interventions

Group 1

Intervention: Pregabalin

Group 2

Intervention: Placebo/Lactose

Outcomes

Primary Outcomes

Pain scores and morphine consumption post surgery

Time Frame: 6 months

Secondary Outcomes

To determine the occurrence of opioid-related side effects such as nausea, vomiting, and respiratory depression in patients receiving pregabalin compared to those receiving placebo.(6 days)