NCT05291663Unknown不适用
Retrospective Study of Effect of Accelerated Radiation Therapy , Six Fractions Per Week , for Squamous Cell Carcinoma of Head and Neck.
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 主要终点
- Determine progression-free survival rate
研究概览
简要总结
Evaluation of the efficacy of the accelerated radiotherapy in squamous cell carcinoma of head and neck
详细描述
- HNSCC is the sixth most common cancer worldwide, with 890.000 new cases and 450.000 deaths in 2018.
- The incidence of HNSCC continues to rise and is anticipated to increase by 30% (that is, 1.08 million new cases annually) by 2030.
- Squamous cell carcinoma constitutes 90% of all head and neck cancers and it predominates in males.
- Risk factors such as cigarette consumption and alcohol consumption, are well established.
- Treatment decisions are guided by clinic-pathologic factors such as age and stage.
- Treatment of the majority of patients with HNSCC requires multimodality approaches.
- Radiotherapy or surgery alone can be considered as the standard treatment modality for patients having early head and neck squamous cell carcinoma.
- When conventionally fractionated radiotherapy is used, long-term tumor control can be achieved in less than 30% of patients with advanced head and neck carcinomas.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients of (18 up to 75 years of age)
- •Performance status of 0-2 according to ECOG scale.
- •Patients with no prior chemotherapy, radiotherapy or surgery except for biopsy.
排除标准
- •Patients with previous irradiation to head and neck.
- •Pregnant or lactating women.
- •Patients with impaired heart or lung diseases.
结局指标
主要结局
Determine progression-free survival rate
时间窗: Baseline
Determine the toxicity and loco-regional control by using accelerated RTH in squamous cell carcinoma in head and neck
次要结局
未报告次要终点
研究者
Zienab Kamel Mahmoud
Doctor
Assiut University
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