Diagnosis and Intervention of Complicated Twin Diseases in China
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Change of volume of amniotic fluid in Milliliter
研究概览
简要总结
Fetal medicine in China is still a new, young discipline, and the development is very rapid. After nearly 10 years of development, the clinical diagnosis and treatment guidelines of some complicated twin diseases has been established , but they are still needed to be improved. Through this study, the investigators expect to achieve better prediction indicators and early intrauterine precise diagnosis of complicated twin diseases. Also, better procedures of implementing effective intrauterine intervention and assessing the safety and effectiveness of intrauterine intervention are anticipated to be established.
详细描述
A better guideline for complicated twin diseases are anticipated to be established in China. Molecular genetics and imaging technology are applied to evaluate the outcome and prognosis of intrauterine intervention for complex twin diseases. 3D printing technology is used to assist the preoperative evaluation of fetal intrauterine intervention. Better fetal intrauterine intervention technique and prognosis evaluation are expected to be established.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Pregnancy women with complicated twin diseases who are able to withstand intrauterine treatment and consent informed.
排除标准
- •Pregnancy women who refuse intrauterine treatment.
结局指标
主要结局
Change of volume of amniotic fluid in Milliliter
时间窗: At every two week from the sixteenth week of gestational age to delivery of babies
Measured by doctors of sonography
Change of umbilical artery blood flow
时间窗: At every two week from the sixteenth week of gestational age to delivery of babies
Measured by doctors of sonography
Gene expression of fetuses
时间窗: At 20 week of gestational age
DNA methylation, histone acetylation etc. assessed by analyses of fetal blood and amniotic fluid.
次要结局
- Neurodevelopment at early childhood(At age of 1 year old)
研究者
Caixia Liu
Director of the second obstetrical department
Shengjing Hospital