Comparative study of intra articular high molecular hyaluronic acid and para articular dextrose prolotherapy in mild to moderate knee osteoarthritis.
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Visual Analogue Scale (VAS)
研究概览
简要总结
Osteoarthritis is a common disease of old age. Conservative methods like exercises and analgesics are the first step towards the treatment. Minimally invasive therapy for OA like high molecular weight hyaluronic acid is a standard treatment. However because of its cost it is not always affordable for all patients in a developing country like india. Intra articular and para articular dextrose is a novel treatment with no serious side effect and is very cheap.
The aim of the present study was to compare the effects of the above two interventions with visual analogue scale and Western Ontario and Mcmaster University arthritis index.
Thirty patients were randomly divided into groups of fifteen each. One received intra articular and para articular dextrose and the second group received high molecular weight hyaluronic acid. Single injection in each group.
There was significant improvement in VAS and WOMAC score in the dextrose group when compared to hyaluronan group (p=0.011 and p=0.004,p<0.05 significant) at post procedure assessment at two months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 50.00 Month(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Knee pain 2.Kellgren Lawrence grade I II III.
排除标准
- •1.Systemic disease 2.On anticoagulants 3.Previous intra articular steroid injection 4.Knee inflammation/ infection 5.Use of steroids in past two weeks.
结局指标
主要结局
Visual Analogue Scale (VAS)
时间窗: two months
次要结局
- Western Ontario and Mcmaster University Arthritis Index (WOMAC)