NCT02627261已完成不适用
Comparison of Three Methods to Evaluate Residual Disease in Multiple Myeloma
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 3
- 主要终点
- Quantification of residual disease
研究概览
简要总结
Three methods including flow cytometry, next generation sequencing and determination of circulating tumor cells will be performed at different time points in patients with previously undiagnosed multiple myeloma in order to determine the most sensitive method to detect residual disease
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •≥ 18 years
- •previously undiagnosed myeloma
- •eligible for high dose therapy and bone marrow transplantation
- •signed consent
排除标准
- •ongoing therapy for another neoplasia
- •Patients with other hematologic malignancies,
- •patients deprived of liberty for administrative or judicial reasons
- •previously treated for myeloma
结局指标
主要结局
Quantification of residual disease
时间窗: Residual disease is assessed up to 18 months after inclusion
study the sensitivity of the method of quantification of circulating tumor cells compared to 2 others methods of detection
次要结局
- kinetic of variation of the circulating tumor cells(18 months)
- kinetic of variation of the residual tumor cells detected by flow cytometry method(18 months)
- kinetic of variation of the residual tumor cells detected by new generation sequencing method(18 months)
研究者
研究点 (3)
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