Can changes in joint fluid explain cartilage repair after joint distraction?<br>

Completed

• Conditions: joint degeneration; osteoarthritis; 10023213

• Registration Number: NL-OMON47444
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Patients with knee joint degeneration (osteoarthritis) eligible in regular clinical practice for knee joint distraction.
For the study specific: written IC based on PIF for 3 intra-articular joint fluid needle aspirations.

Exclusion Criteria

Unable to undergo knee joint distraction in regular clinical practice.
For the study specific exclusion criteria: unable to provide written IC based on written (PIF) and oral study information for 3 intra-articular joint fluid needle aspirations.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Change in joint homeostasis. Joint homeostasis is a complex of soluble<br /><br>mediators and cells responsible for the integrity (e.g. nutrition, maintenance,<br /><br>and turnover) of the cartilage tissue (note: cartilage is not vascularised and<br /><br>thus for its mediators dependent on exchange with the joint fluid). There will<br /><br>be a focus on changes in i) growth factors, ii) proteases, iii) proinflammatory<br /><br>cytokines, iv) pro-inflammatory cells, and v) stem cells.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>NA</p><br>