Evaluation Of Antimicrobial Potency Of A Novel Cinnamon Extract Irrigant Versus Sodium Hypochlorite Irrigant Following Pulpectomy Of Primary Teeth . (A Randomized Clinical Trial)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- Change in bacterial count.
研究概览
简要总结
The aim of the study is to evaluate effectiveness of cinnamon extract versus sodium hypochlorite as root canal irrigant for in pulpectomy of primary teeth in reduction of bacterial count .
详细描述
Preservation of primary teeth with non-vital pulp is a major problem in pediatric dentistry, as it is a poly-microbial and dominated by obligatory anaerobic bacteria. Regarding these case preferable treatment modality is pulpectomy . The objective of pulpectomy is complete removal of necrotic and irreversibly infected pulp of an affected tooth but due to limited ability of mechanical preparation to eliminate entrapped micro-organisms in the canal space owing to the tortuous and complex nature of the root canal system .Thus, the use of antimicrobial agents has been recommended as an adjunct to mechanical instrumentation in deciduous teeth . Due to potential side effects, safety concerns of synthetic drugs and cytotoxic reactions of commercial intra canal irrigants and their limited ability to eliminate bacteria from dentinal tubules . Finding the best irrigating solution for endodontic therapy in primary and permanent teeth is still a working progress .There is a growing interest in using sustainable products of natural origin as an alternative to commercially available industrial ones .Cinnamon , which has gained popularity in recent time due its antibacterial , antifungal , anti-inflammatory & antiseptic activity . It has shown effectiveness against S. mutans and E. fecalis organisms . It is also known to show a wide spectrum of action on gram positive and gram negative bacteria .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 4 Years 至 8 Years(Child)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Children:
- •Aged 4 to 8, in good general health, and medically free.
- •Cooperative patients who will comply to dental treatment .
- •Parents provided with written informed consent.
- •No previous history of antibiotics administration or last dose was taken from at least 2 weeks.
- •Carious primary molars with irreversible pulpitis.
- •Presence of localized swelling ,sinus and pain on percussion which indicate non vital pulp .
- •Presence of periapical and furcation radiolucency .
- •In periapical radiograph teeth have no more than 1/3 of root resorption.
排除标准
- •Children:
- •Children with medical, physical, or mental conditions.
- •Severly Uncooperative children .
- •Primary molars with any congenital anomalies.
- •Teeth with un-restorable crowns .
- •Root resorbtion more than half of the root.
结局指标
主要结局
Change in bacterial count.
时间窗: Day 1
Quantitative.(Colony Forming Unit ) take sample by paper point before and after irrigation by control of interventional
次要结局
- post operative pain evaluation(6,12,24,48,72 hour)
研究者
Amany Hossam
Principle Investigator
Cairo University
