Comparative evaluation of the effect of denture adhesives with probiotics on colony forming units of candida and retention in completely edentulous patients wearing complete dentures. A randomized controlled trial.

This study is a randomised controlled trial with a cross over design to find out the effect of probiotics added to denture adhesives on the colony forming units of candida in the oral cavity in complete denture wearers and its effect on retention of the denture . It has been proved that probiotics bring down the candida infection level  in oral cavity in complete denture patients.A trial product was generated where probiotics of the total power of 10raise to power 8 containing lactobacillus rhamnosus,lactobacillus acidophilus and bifidobacterium bifidum. the primary outcome assessed will be CFU/uL and retention in Complete denture patients in N-Cm.  Candida is a normal commensal of the oral cavity but it can become can turn pathogenic in patients who are immunocompromised.Denture adhesives enhance retention in the dentures.Therefore they are commonly prescribed in denture wearing patients. It has also been shown that denture adhesives can increase the risk of candida in denture wearing patients if they do not maitain hygiene adequately. therefore there was need to generate a product which can enhance the retention of the denture at the same time prevent candida growth under the denture in healthy and in immunocompromised patients.