Comparison of Preoperative Nebulization of Dexmedetomidine Versus Lignocaine in Attenuating Hemodynamic Response to Direct Laryngoscopy and Endotracheal Intubation in Patients Undergoing Elective Laparoscopic Surgeries: A Randomized Double Blinded Clinical Study
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- To evaluate the effects of preoperative nebulized Dexmedetomidine (1mcg per kg) and Nebulized Lignocaine 4% (3mg per kg) on the hemodynamic response to laryngoscopy and intubation by monitoring vitals
研究概览
简要总结
**Direct laryngoscopy and tracheal intubation following induction of anaesthesia are associated with hemodynamic changes due to increased sympathoadrenal activity which may result in hypertension and tachycardia.****Multiple drugs have been used to blunt the hemodynamic response during endotracheal intubation one of them is Dexmedetomidine which is a highly selective alpha 2 agonist which has sympatholytic, sedative analgesic and amnestic properties.****Another drug is Lignocaine which is an amide local anaesthetic which reduces the excitation of airway sensory fibres.**Thus, in this study we compare the effects of pre-operative nebulization of Dexmedetomidine 1mcg/kg and 4% Lignocaine 3mg/kg on the haemodynamic response during endotracheal intubation in Patients Undergoing Elective laparoscopic surgeries.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients willing to give informed written consent
- •American Society of Anaesthesiologists class I and II 3.Patients with normal airway on examination 4.Patients undergoing elective laparoscopic surgeries under general anaesthesia with endotracheal intubation with a duration of 2 to 4 hours are included in the study.
排除标准
- •1.Individuals with BMI more than 30 kg per meter square 2.Mallampati grading more than 2 3.Anticipated difficult intubation requiring more than 15 seconds for intubation or more than two attempts at laryngoscopy 4.Patients with allergy to Dexmedetomidine and Lignocaine 5.Taking medicines such as Beta blockers, Clonidine, Gabapentin, Pregabalin, Anti-convulsant, Anti-psychotics
- •Pregnant patients are excluded from the study.
结局指标
主要结局
To evaluate the effects of preoperative nebulized Dexmedetomidine (1mcg per kg) and Nebulized Lignocaine 4% (3mg per kg) on the hemodynamic response to laryngoscopy and intubation by monitoring vitals
时间窗: Post Intubation at 1min, 3min, 5min, 10min, 15min, 30min, 45min, 60min, 90min, 120min, 150min, 180min, 210min and 240min.
次要结局
- Amount of Inj Fentanyl consumed intra-operatively(Post Intubation at 1min, 3min, 5min, 10min, 15min, 30min, 45min, 60min, 90min, 120min, 150min, 180min, 210min and 240min.)
研究者
Dr Harshith P Gowda
BGS Global Institute of Medical Sciences