Cyclo-oxygenase inhibition and muscular function in hospitalised geriatric patients with inflammatio

Completed

• Conditions: Infection-induced inflammation and related muscle weakness; Not Applicable

• Registration Number: ISRCTN58517443
• Lead Sponsor: Brussels University Hospital (Belgium) (Universitair Ziekenhuis Brussel)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-04-28
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Patients hospitalised in an acute geriatric ward
2. Age > 70 years
3. Inflammation, not due to surgery or burns, and documented by an increase of serum concentration of C-reactive protein (CRP) (> 10 mg/L) and/or fibrinogen (>400 mg/dL)
4. Informed consent

Exclusion Criteria

1. General condition, dementia or confusion, not allowing the testing
2. Patients in (pre) terminal phase
3. Use of corticosteroids or non -steroidal anti-inflammatory drugs (NSAIDs) in the past 7 days; the use of inhalation corticosteroids, of low dose aspirin (as anti-aggregating medication) or of paracetamol is allowed
4. Contra-indication for the use of cyclo-oxygenase (COX)-2 inhibitors

Study & Design

• Study Type: Interventional
• Study Design: Not specified