The Comparison of Uniportal and Tubeless Video Assisted Thoracic Surgery and Transbronchial Lung Cryobiopsy in the Diagnosis of Interstitial Lung Disease
Not Applicable
- Conditions
- Surgical Lung BiopsyTransbronchial Lung CryobiopsyInterstitial Lung Disease
- Registration Number
- NCT03958162
- Lead Sponsor
- Guangzhou Institute of Respiratory Disease
- Brief Summary
To compariing the uniportal and tubeless video assisted thoracic surgery and trnsbronchial lung cryobiopsy within the multidisciplinary discussion context in the diagnosis of interstitial lung disease，and assess the safety and cost-effectiveness. This is a prospective control trial.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- 18 yrs ≤ age<75yrs
- Patients diagnosed as interstitial lung disease with comprehensive clinical data (including history, serological test, spirometry test and high resolution computed tomography)
- Further pathological data was still required after multidisciplinary discussion.
Exclusion Criteria
- Severe pulmonary dysfunction: forced vital capacity (FVC) ≤65% or carbon-monoxide diffusion coefficient (DLco) ≤45% of predicted value
- Pulmonary hypertension: An estimated systolic pulmonary artery pressure>50mmHg on echocardiography
- Abnormal coagulation parameters or thrombocytopenia (<50*109/L)
- Severe comorbidities leading to inoperable condition
- Patients cannot give consent or refuse biopsy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Diagnotic yield two weeks Percentage of definitive diagnosis within the multidisciplinary discussion context by two different biopsy methods
- Secondary Outcome Measures
Name Time Method