Plasma Levels of Micro RNA 203 and 210 Might Spare the Exploratory Laparoscopy in Case of un Explained Infertility With Suspected Endometriosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- grading of endometriosis
研究概览
简要总结
The study targets to evaluate the role of estimation of plasma expression levels of gene of microRNAs 203 and 210 in helping to diagnose and grade endometriosis. The study included women with unexplained infertility and clinical picture suggestive of presence of endometriosis were divided randomly into two groups: Control and study groups. All patients underwent exploratory laparotomy for diagnosis and grading of endometriosis if present. Patients of study group gave blood samples for estimation of plasma expression levels of microRNA 203 and 210 using qRT-PCR procedure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 30 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •30-45 years old
- •Unexplained infertility
排除标准
- •Presence of other causes of infertility,
- •age out of the predetermined range,
- •the presence of immune disorders,
- •maintenance on immunosuppressive drugs
研究组 & 干预措施
Control Group
Control group Patients with unexplained infertility underwent laparoscopy only
干预措施: Laparoscopic Exploration (Procedure)
Study group
Study group Patients with unexplained infertility had estimated their Plasma Expression level for Gene"Micro RNA "203 & 210" by qRT-PCR followed by laparoscopic exploration
干预措施: Laparoscopic Exploration (Procedure)
Study group
Study group Patients with unexplained infertility had estimated their Plasma Expression level for Gene"Micro RNA "203 & 210" by qRT-PCR followed by laparoscopic exploration
干预措施: Estimation of Plasma Expression level of MICRO RNA 203 & 210 (Diagnostic Test)
结局指标
主要结局
grading of endometriosis
时间窗: 8 months
The diagnostic performance of estimated plasma levels of microRNA for diagnosis and grading endometriosis
次要结局
未报告次要终点
研究者
Amr Sharaf Eldein
Assistant professor of gynecology
Benha University