The Translational Initiative to Map Epigenetics in Aging (TIME-A)

Not yet recruiting

• Conditions: Biological Aging

• Registration Number: NCT05760547
• Lead Sponsor: Elysium Health

Brief Summary

The Translational Initiative to Map Epigenetics in Aging (TIME-A) study aims to advance our understanding of the connections between epigenetics, lifestyle, demographics, and health and aging.

Detailed Description

TIME-A is a longitudinal research initiative. Anyone who has ever taken an Index test registered through Elysium Health is eligible to participate. Participation involves answering questions that will be administered via a survey format. Research participants' survey responses will be combined with their epigenetic Index data with the primary aim of identifying the contributions of 1) environmental and lifestyle factors, 2) general health, and 3) medical history, on biological age. Exploratory aims include the development of epigenetic signatures that are predictive of health status, and exploring the relationship between epigenetically-derived health phenotypes and biological age. These findings will lay the foundation for personalized health recommendations using Index (including, but not limited to: workout routines, diets, supplement regimens, medications, lifestyle changes).

Study Timeline

• Status Verified: 2023-02
• Study First Submitted: 2023-02-09
• Study First Submitted QC: 2023-02-27
• Last Update Submitted: 2023-02-27
• Study Start: 2023-03-08
• Study First Posted: 2023-03-08
• Last Update Posted: 2023-03-08
• Primary Completion: 2033-03-31
• Study Completion: 2033-03-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 25000

Inclusion Criteria

• All adults aged 18 and above
• Have registered at least one Index kit via the Elysium Health website
• Able and willing to provide digital consent to the Research Consent Form, and the TIME-A Research Subject Consent Form

Exclusion Criteria

• Consent to participate not given

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effect of environmental and lifestyle factors on biological age	At baseline and throughout study (approximately every 6 months up to 120 months)	Univariate and multivariate statistical methods will be used to identify which environmental and lifestyle factors (from TIME-A survey responses) influence biological age.
Effect of general health on biological age	At baseline and throughout study (approximately every 6 months up to 120 months)	Univariate and multivariate statistical methods will be used to identify which general health characteristics (from TIME-A survey responses) influence biological age.
Effect of medical history on biological age	At baseline and throughout study (approximately every 6 months up to 120 months)	Univariate and multivariate statistical methods will be used to identify the impact of medical history (from TIME-A survey responses) on biological age.