The Translational Initiative to Map Epigenetics in Aging (TIME-A)
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 25,000
- 主要终点
- Effect of environmental and lifestyle factors on biological age
研究概览
简要总结
The Translational Initiative to Map Epigenetics in Aging (TIME-A) study aims to advance our understanding of the connections between epigenetics, lifestyle, demographics, and health and aging.
详细描述
TIME-A is a longitudinal research initiative. Anyone who has ever taken an Index test registered through Elysium Health is eligible to participate. Participation involves answering questions that will be administered via a survey format. Research participants' survey responses will be combined with their epigenetic Index data with the primary aim of identifying the contributions of 1) environmental and lifestyle factors, 2) general health, and 3) medical history, on biological age. Exploratory aims include the development of epigenetic signatures that are predictive of health status, and exploring the relationship between epigenetically-derived health phenotypes and biological age. These findings will lay the foundation for personalized health recommendations using Index (including, but not limited to: workout routines, diets, supplement regimens, medications, lifestyle changes).
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All adults aged 18 and above
- •Have registered at least one Index kit via the Elysium Health website
- •Able and willing to provide digital consent to the Research Consent Form, and the TIME-A Research Subject Consent Form
排除标准
- •Consent to participate not given
结局指标
主要结局
Effect of environmental and lifestyle factors on biological age
时间窗: At baseline and throughout study (approximately every 6 months up to 120 months)
Univariate and multivariate statistical methods will be used to identify which environmental and lifestyle factors (from TIME-A survey responses) influence biological age.
Effect of general health on biological age
时间窗: At baseline and throughout study (approximately every 6 months up to 120 months)
Univariate and multivariate statistical methods will be used to identify which general health characteristics (from TIME-A survey responses) influence biological age.
Effect of medical history on biological age
时间窗: At baseline and throughout study (approximately every 6 months up to 120 months)
Univariate and multivariate statistical methods will be used to identify the impact of medical history (from TIME-A survey responses) on biological age.
次要结局
未报告次要终点