Influence of altitude on cerebral and splanchnic oxygen saturation in critically ill children during air ambulance transport

Not Applicable

Completed

• Conditions: Critical illness; Respiratory - Normal development and function of the respiratory system

• Registration Number: ACTRN12619001710112
• Lead Sponsor: Karolinska University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2019-01-22
• Study Start: 2019-12-04
• Last Update Posted: 10 December 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 39

Inclusion Criteria

Children scheduled for inter-hospital transport by a specialized pediatric transport team at the Pediatric Intensive Care Unit (PICU) at the Astrid Lindgren Children’s Hospital, Karolinska University Hospital in Stockholm, Sweden.

Exclusion Criteria

Flights with an estimated duration less than 50 minutes and flights with a need for sea level cabin altitude. Lack of informed consent, participation in any other clinical research study,

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
umber and percentage of patients with cerebral oxygen saturation levels effected 20% or more compared to ground levels. This is assessed by comparing cerebral NIRS values before flight, at sea level, with those during flight at altitude of 5000 feet or higher. Data are extracted from the NIRS monitor after the transport.[Direct after completion of patient transport];The number and percentage of patients with splanchnic<br>oxygen saturation levels effected 20% or more compared to sea level. This is assesses by comparing splanchnic NIRS values before flight, at sea level, with those during flight at altitude of 5000 feet or higher. Data are extracted from the NIRS monitor after the transport.[Direct after completion of patient transport]

Secondary Outcome Measures

Name	Time	Method
umber and percentage of patients with cyanotic heart malformations who develop a difference of 20% or more in cerebral and splanchnic oxygen saturation during flight with cabin pressurization corresponding to 5000 feet or higher compared to levels at sea level. This is assesses by comparing NIRS values before flight, at sea level, with those during flight at altitude of 5000 feet or higher. Data are extracted from the NIRS monitor after the transport.[After collection of all patient data];Number and percentage of patients with non-cyanotic heart malformations who develop a difference of 20% or more in cerebral and splanchnic oxygen saturation during flight with cabin pressurization corresponding to 5000 feet or higher compared to levels at sea level. This is assesses by comparing NIRS values before flight, at sea level, with those during flight at altitude of 5000 feet or higher. Data are extracted from the NIRS monitor after the transport.[After collection of all patient data]