The effect of ondansetron, a 5-Ht3 receptor antagonist, on fatigue severity and functional impairment in Chronic Fatigue Syndrome patients
Completed
- Conditions
- Chronic fatigue syndromeNervous System Diseases
- Registration Number
- ISRCTN02536681
- Lead Sponsor
- niversity Medical Centre Nijmegen (Netherlands)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
1. CDC-diagnosed CFS-patients
2. Male and female patients 18 - 65 years of age
3. High-fatigue severity level
4. Substantial functional impairment
5. Written informed consent
Exclusion Criteria
1. Pregnancy
2. Lactating women
3. Participation in CFS-treatment programs
4. Participation in other CFS-research
5. Psychopharmaca
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Fatigue severity: measured with Checklist Individual Strength<br>2. Functional impairment: measured with Sickness Impact Profile<br>3. CDC-symptoms
- Secondary Outcome Measures
Name Time Method Physical activity level: measured with actometer<br>