Dynamic Assessment of Right Ventricular Function With Inhaled Nitric Oxide During Cardiac MRI
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 17
- 试验地点
- 1
- 主要终点
- Right ventricular ejection fraction (RVEF) before and after inhaled nitric oxide exposure
研究概览
简要总结
The purpose of the study is to measure RV ejection fraction (RVEF), pulmonary flow, and pulmonary perfusion before and after exposure to inhaled nitric oxide in patients with pulmonary arterial hypertension (PAH) who are known to be vasodilator-responsive based on invasive catheterization as well as healthy subjects. Measurements will also be made after high flow oxygen alone to test the relative vasodilatory effect of oxygen and NO. The investigators hypothesize is that inhaled nitric oxide during cardiac MRI can be used to measure dynamic changes in RV-pulmonary vascular function in patients with vasodilator-responsive PAH.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients age 18 or older of the Vanderbilt Center for Pulmonary Vascular Disease. Vasodilator-responsive patients will be identified based on prior response to inhaled nitric oxide during invasive right heart catheterization
- •Healthy subjects age 18 or older not known to have cardiopulmonary disease
排除标准
- •Standard conventional contraindications for cardiac magnetic resonance (CMR) imaging
- •Allergy or contraindication to Magnevist (gadopentetate dimeglumine) contrast
- •Concurrent intravenous epoprostenol infusion in whom performance of CMR is cumbersome
- •Pregnant women
研究组 & 干预措施
Nitric Oxide
40 ppm, one time administration, inhaled.
干预措施: INOmax Inhalation (Drug)
结局指标
主要结局
Right ventricular ejection fraction (RVEF) before and after inhaled nitric oxide exposure
时间窗: At time of procedure
次要结局
- Pulmonary transit time(At baseline, after 4 minutes high flow oxygen, after 4 minutes high flow oxygen plus nitric oxide)
- Pulmonary flow(Baseline, after 4 minutes high flow oxygen, after 4 minutes high flow oxygen plus nitric oxide)
- Pulmonary perfusion(Baseline, after 4 minutes of high flow oxygen, after 4 minutes of high flow oxygen plus nitric oxide)
- Estimates of pulmonary vascular resistance(At Baseline, after 4 minutes of high flow oxygen, after 4 minutes of high flow oxygen plus nitric oxide)
- Pulmonary artery compliance(At baseline, after 4 minutes high flow oxygen, after 4 minutes high flow oxygen plus nitric oxide)
研究者
Evan Brittain
Assistant Professor
Vanderbilt University