Dynamic Assessment of Right Ventricular Function With Inhaled Nitric Oxide During Cardiac MRI
Overview
- Phase
- Early Phase 1
- Intervention
- INOmax Inhalation
- Conditions
- Pulmonary Vascular Disorder
- Sponsor
- Vanderbilt University
- Enrollment
- 17
- Locations
- 1
- Primary Endpoint
- Right ventricular ejection fraction (RVEF) before and after inhaled nitric oxide exposure
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of the study is to measure RV ejection fraction (RVEF), pulmonary flow, and pulmonary perfusion before and after exposure to inhaled nitric oxide in patients with pulmonary arterial hypertension (PAH) who are known to be vasodilator-responsive based on invasive catheterization as well as healthy subjects. Measurements will also be made after high flow oxygen alone to test the relative vasodilatory effect of oxygen and NO. The investigators hypothesize is that inhaled nitric oxide during cardiac MRI can be used to measure dynamic changes in RV-pulmonary vascular function in patients with vasodilator-responsive PAH.
Investigators
Evan Brittain
Assistant Professor
Vanderbilt University
Eligibility Criteria
Inclusion Criteria
- •Patients age 18 or older of the Vanderbilt Center for Pulmonary Vascular Disease. Vasodilator-responsive patients will be identified based on prior response to inhaled nitric oxide during invasive right heart catheterization
- •Healthy subjects age 18 or older not known to have cardiopulmonary disease
Exclusion Criteria
- •Standard conventional contraindications for cardiac magnetic resonance (CMR) imaging
- •Allergy or contraindication to Magnevist (gadopentetate dimeglumine) contrast
- •Concurrent intravenous epoprostenol infusion in whom performance of CMR is cumbersome
- •Pregnant women
Arms & Interventions
Nitric Oxide
40 ppm, one time administration, inhaled.
Intervention: INOmax Inhalation
Outcomes
Primary Outcomes
Right ventricular ejection fraction (RVEF) before and after inhaled nitric oxide exposure
Time Frame: At time of procedure
Secondary Outcomes
- Pulmonary transit time(At baseline, after 4 minutes high flow oxygen, after 4 minutes high flow oxygen plus nitric oxide)
- Pulmonary flow(Baseline, after 4 minutes high flow oxygen, after 4 minutes high flow oxygen plus nitric oxide)
- Pulmonary perfusion(Baseline, after 4 minutes of high flow oxygen, after 4 minutes of high flow oxygen plus nitric oxide)
- Estimates of pulmonary vascular resistance(At Baseline, after 4 minutes of high flow oxygen, after 4 minutes of high flow oxygen plus nitric oxide)
- Pulmonary artery compliance(At baseline, after 4 minutes high flow oxygen, after 4 minutes high flow oxygen plus nitric oxide)