Onderzoek naar de samenstelling van afweercellen in Psoriasis Artritis en Psoriasis.
- Conditions
- psoriatic arthritisT-cellAntigenreceptor
- Registration Number
- NL-OMON25716
- Lead Sponsor
- Erasmus Medical CentreDepartment of Dermatology
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
PsA group:
Adults patients (18-75 years of age, after informed consent), with joint inflammation of one or both knees due to PsA requiring systemic treatment. The patients have failed to respond to, or have a contraindication for cyclosporine and other DMARDS except MTX.
Exclusion Criteria
1. Pregnancy and lactation;
2. Active (or chronic) infections including Hepatitis B and C viral infections, HIV and tuberculosis;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. The difference(s) in T-cell receptor (TCR-G) profile between psoriatic skin lesions and inflamed knee joint in PsA patients;<br /><br>2. The difference(s) in T-cell receptor (TCR-G) profile between psoriatic skin lesions in psoriasis patients and psoriatic skin lesions in PsA patients;<br /><br>3. The difference(s) in T cell gene expression profile from psoriatic skin lesions in psoriasis patients and psoriatic skin lesions of PsA patients;<br /><br>4. Gene expression profile of T cells from inflamed knee joint of PsA patients.<br><br>
- Secondary Outcome Measures
Name Time Method Effects of therapy on pathogenic T cells and their gene expression profile in PsA and psoriasis.