Clinical trial of Intracoronary Thrombolysis with Tenecteplase in premature age patients (under 40yrs) with Heart attack.

Not Applicable

• Conditions: Health Condition 1: I219- Acute myocardial infarction, unspecified

• Registration Number: CTRI/2018/10/016213
• Lead Sponsor: DR C N MANJUNATH

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

(a) Men aged 40 years old or younger

(b) Women aged 40 years old or younger

(c) Presentation to hospital < 6 hours after the index pain.

(d) All patients with diagnosis of STEMI, as evidenced by:

• Detection of a rise and/or fall in cardiac biomarker value (Trop-T), with at least one value above the 99th percentile of the upper reference range and with at least one of the following:

-Symptoms of ischemia

-New or presumed new significant ST-segment T wave (ST-T) changes or new LBBB

-Development of pathologic Q waves on the ECG

-Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality

-Identification of an intracoronary thrombus by angiography

Exclusion Criteria

(a)Patients with previous history of ischemic heart disease/ PTCA / CABG.

(b)Patients with history of cardiomyopathy

(c)Patients with mechanical complications of STEMI

(d)Resuscitated Cardiac Arrest, severe LV dysfunction, Kilip-III and IV on presentation to hospital.

(e)Patients with unstable haemodynamics

(f)Patients with absolute contraindications for the use of fibrinolytic agents:

-Any previous intracranial haemorrhage

-Known structural cerebral vascular lesion (e.g., arteriovenous malformation)

-Known malignant intracranial neoplasm (primary or metastatic)

-Ischemic stroke within 3 months except acute ischemic stroke within 4.5 hours

-Suspected aortic dissection

-Active bleeding or bleeding diathesis (excluding menses)

-Significant closed-head or facial trauma within 3 months

-Intracranial or intraspinal surgery within 2 months

-Severe uncontrolled hypertension (unresponsive to emergency therapy)

(g)Patients having a history of diabetes mellitus, chronic alcoholism, concomitant liver, kidney disease, cerebrovascular disease and acute / chronic infection

(e) Patients unwilling to give informed consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified