Effects of exercise in childhood brain cancer survivors

Not Applicable

Active, not recruiting

• Conditions: Childhood brain cancer (childhood posterior fossa brain tumours); Cancer - Brain; Physical Medicine / Rehabilitation - Physiotherapy; Physical Medicine / Rehabilitation - Other physical medicine / rehabilitation

• Registration Number: ACTRN12619000841178
• Lead Sponsor: Prof Stewart Trost

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-06-12
• Last Update Posted: 26 September 2023

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Eligibility criteria: (1) Children (5 to 17 years); (2) diagnosis of a PFBT that required surgery at least 12 months earlier, with no maximum time since surgery as long as the participant meets the age eligibility criterion; (3) no chemotherapy or radiation therapy received in the last 6 months; (4) no evidence of progressive disease; and (5) medically able to complete an exercise program.

Exclusion Criteria

(1) insufficient English to complete study assessments or participate in the exercise intervention; (2) the study is not suitable as assessed by the treating oncologist; (3) concurrent medical condition that would prohibit exercise testing or may jeopardise the ability of the patient to undergo the exercise intervention with reasonable safety; (4) participants is unable to travel to research facility for intervention sessions and there are no participating physiotherapists in their local area who can deliver the intervention or to the research facility to complete study assessments.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cardiorespiratory fitness (VO2 peak) as assessed by an electronically-braked paediatric cycle ergometer[ All primary outcomes are assessed at baseline, 12 weeks after intervention commencement (primary time point), 6 months following the 12 week assessment, and at 12-months following the 12 week intervention];Submaximal endurance using the Modified Shuttle Test (MST)[ All primary outcomes are assessed at baseline, 12 weeks after intervention commencement (primary time point), 6 months following the 12 week assessment, and at 12-months following the 12 week intervention];Goal attainment using the Canadian Occupational Performance Measure (COPM)[ All primary outcomes are assessed at baseline, 12 weeks after intervention commencement (primary time point), 6 months following the 12 week assessment, and at 12-months following the 12 week intervention. ]