Physiological effects of goal directed therapy (incorportating dopexamine infusion) in patients undergoing major surgery

Completed

• Conditions: Abdominal surgery; Major abdominal surgery; Surgery

• Registration Number: ISRCTN94850719
• Lead Sponsor: Queen Mary's University of London (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2007-01-29
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 135

Inclusion Criteria

All adult patients admitted to intensive care or high dependency unit following elective major abdominal surgery

Exclusion Criteria

1. Refusal of consent
2. Concurrent lithium therapy
3. Acute myocardial ischaemia
4. Acute arrhythmias
5. Pregnancy
6. Patients receiving palliative treatment only
7. Weight less than 40 kg

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduction in post-operative complication rates associated with the use of Goal Directed Therapy.<br><br>Added as of 23/10/2007:<br>Increase in tissue oxygenation associated with the use of Goal Directed Therapy.

Secondary Outcome Measures

Name	Time	Method
1. Reduction in microvascular perfusion associated with the use of Goal Directed Therapy <br>2. Reduction in tissue oxygenation associated with the use of Goal Directed Therapy <br>3. Reduction in post-operative duration of hospital stay associated with the use of Goal Directed Therapy<br>4. Reduction in post-operative mortality associated with the use of Goal Directed Therapy