ong-term pain modulation by intravenous esketamine in Complex Regional Pain Syndrome: a non-inferiority study
- Conditions
- Complex Regionaal Pijn Syndroom (CRPS)Complex Regional Pain Syndromereflex sympathetic dystrophy
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 60
- Age >= 18 years.
- Meeting the new International Association for the Study of Pain (IASP)
diagnostic criteria for CRPS (*the Budapest Criteria) or having met the new
IASP diagnostic criteria of CRPS (*CRPS with Remission of Some features*)
(Harden et al. 2010) (Goebel et al. 2021)
- Willing and capable to participate in the study.
- CRPS in one upper extremity and/or CRPS in one lower extremity
- Treatment in an elective setting.
- Adequate comprehension of the Dutch language
Contraindications to and precautions for use of subanesthetic doses of ketamine
for chronic pain are listed by Cohen et al. and the Dutch CRPS guidelines and
our clinical protocol (Cohen et al. 2018; Perez et al. 2014). For each patient,
the contraindications and precautions for use of esketamine infusions for CRPS
patients will be checked/assessed by their treating pain specialist. If a
patient has no contraindications for esketamine treatment and the patient is
eligible for esketamine treatment according to the Dutch CRPS guidelines, the
patient will be placed on the waiting list. In this study we only select
patients from the waiting list for esketamine treatment of the Center for Pain
medicine.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Pain intensity measured by Numerical Rating Scale (NRS):<br /><br>- The average NRS score of the last 24 hours<br /><br>- The current NRS score reflecting the pain intensity at the moment when asked </p><br>
- Secondary Outcome Measures
Name Time Method