The Chinese Early-onset Hypertension Study (CHESS)

• Conditions: Hypertension

• Registration Number: NCT02819674
• Lead Sponsor: China National Center for Cardiovascular Diseases

Brief Summary

Hypertension (HTN) is the most important cardiovascular risk factor which is responsible for 50% of cardiovascular morbidity and mortality, and also a substantial public health problem affecting approximately 1/4 of the adult population in industrialized societies and over 1 billion people worldwide. Chronically elevated blood pressure without well control puts people at increased risk of target organ damages, including stroke, myocardial infarction, congestive heart failure, end-stage renal disease, blindness, and death. Especially, these damages are dramatically more severe in the early-onset hypertensive population.

Detailed Description

In this study, the hypertensive individuals are consecutively recruited from multiple centers, with an early onset age (less than 40 when diagnosed). A complete clinical history (information on history of hypertension, demographic characteristics, personal and family medical history) are collected by a trained staff using a standardized questionnaire on the first day of baseline observation, and physical examination are also collected in a standard procedure. Blood samples are collected after 12-hour overnight fast and biological variables are determined. Genomic DNA is isolated from leukocytes according to a standard procedure. The individuals will receive follow-up in an ordinal system. The investigators will focus on the clinical and genetic features, genotype-phenotype correlations and influencing factors of prognosis in Chinese early-onset hypertension patients.

Study Timeline

• Study Start: 2012-10
• Study First Submitted: 2016-05-20
• Study First Submitted QC: 2016-06-29
• Study First Posted: 2016-06-30
• Status Verified: 2018-01
• Last Update Submitted: 2018-01-07
• Last Update Posted: 2018-01-09
• Primary Completion: 2020-12
• Study Completion: 2020-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 5000

Inclusion Criteria

• In accordance with the diagnosis of hypertension (BP≥140/90mmHg), and less than 40 years when diagnosed

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
primary mortality of early-onset hypertension	through study completion, an average of 5 years	the primary mortality of early-onset hypertension

Secondary Outcome Measures

Name	Time	Method
secondary outcomes of heart	through study completion, an average of 5 years	The incidence rate of left ventricular hypertrophy, myocardial infarction, congestive heart failure, and arrhythmia.
secondary outcomes of brain	through study completion, an average of 5 years	The incidence rate of stroke (include cerebral hemorrhage and cerebral ischemia)
secondary outcomes of kidney	through study completion, an average of 5 years	The incidence rate of hypertensive renal injure and end-stage renal disease
secondary outcomes of eyes	through study completion, an average of 5 years	The incidence rate of hypertensive eye injure

Trial Locations

Locations (1)

Fuwai hospital; 🇨🇳 Beijing, Beijing, China