The Chinese Early-onset Hypertension Study (CHESS)
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 5,000
- 试验地点
- 1
- 主要终点
- primary mortality of early-onset hypertension
研究概览
简要总结
Hypertension (HTN) is the most important cardiovascular risk factor which is responsible for 50% of cardiovascular morbidity and mortality, and also a substantial public health problem affecting approximately 1/4 of the adult population in industrialized societies and over 1 billion people worldwide. Chronically elevated blood pressure without well control puts people at increased risk of target organ damages, including stroke, myocardial infarction, congestive heart failure, end-stage renal disease, blindness, and death. Especially, these damages are dramatically more severe in the early-onset hypertensive population.
详细描述
In this study, the hypertensive individuals are consecutively recruited from multiple centers, with an early onset age (less than 40 when diagnosed). A complete clinical history (information on history of hypertension, demographic characteristics, personal and family medical history) are collected by a trained staff using a standardized questionnaire on the first day of baseline observation, and physical examination are also collected in a standard procedure. Blood samples are collected after 12-hour overnight fast and biological variables are determined. Genomic DNA is isolated from leukocytes according to a standard procedure. The individuals will receive follow-up in an ordinal system. The investigators will focus on the clinical and genetic features, genotype-phenotype correlations and influencing factors of prognosis in Chinese early-onset hypertension patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •In accordance with the diagnosis of hypertension (BP≥140/90mmHg), and less than 40 years when diagnosed
排除标准
- 未提供
结局指标
主要结局
primary mortality of early-onset hypertension
时间窗: through study completion, an average of 5 years
the primary mortality of early-onset hypertension
次要结局
- secondary outcomes of heart(through study completion, an average of 5 years)
- secondary outcomes of brain(through study completion, an average of 5 years)
- secondary outcomes of kidney(through study completion, an average of 5 years)
- secondary outcomes of eyes(through study completion, an average of 5 years)
研究者
Lei.Song@NCCD
MD, ph.D
China National Center for Cardiovascular Diseases