Postoperative Serum VEGF Concentration as an Independent Prognostic Factor for Recurrence After Curative Colon Cancer Surgery. Multicentric Study.
试验速览
- 阶段
- 不适用
- 入组人数
- 280
- 主要终点
- VEGF in serum on postop day 4
研究概览
简要总结
The purpose of this trial is to study the relationship between the angiogenic response to surgical aggression, determined through the serum levels of vascular endothelial growth factor (VEGF) on postoperative day four, and the tumor recurrence in patients with colon cancer operated with a curative intention.
详细描述
DESIGN: Prospective multicentric study.
PARTICIPATION: Colorectal Surgery Units of Hospital del Mar, Barcelona; Hospital Universitari Joan XXIII, Tarragona; Hospital Universitari La Fe, Valencia; Hospital Clínico San Carlos, Madrid; Hospital General de Granollers, Granollers; Hospital Germans Trias i Pujol, Badalona; Athalaia, Xarxa Assistencial Universitària de Manresa, Manresa
STUDY SUBJECTS: 280 consecutive patients with non-metastatic colon cancer in whom a curative intent resection is performed.
DETERMINATIONS: Determination of the proangiogenic cytokine VEGF in serum on the postoperative day four to assess its relationship with oncological results on long-term follow-up.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with colon cancer admitted to the Colorectal Surgery Unit of the centers participating in the study,
- •Patients who will undergo elective surgical resection with potentially curative intention
排除标准
- •Patients with metastatic disease
- •Patients with synchronous colon neoplasia or in the previous five years
- •Patients undergoing emergency surgery
- •Patients who do not sign the informed consent.
结局指标
主要结局
VEGF in serum on postop day 4
时间窗: Postoperative day 4
A 10cc sample of peripheral blood will be drawn on postoperative day 4
次要结局
未报告次要终点
研究者
Marta Pascual
CHIEF, COLON AND RECTAL SURGERY, DEPARTMEN OF SURGERY
Hospital del Mar