Deep vs Moderate Neuromuscular Blockade on Surgical Conditions and Quality of Recovery in Day Case Laparoscopic Cholecystectomy
Overview
- Phase
- Phase 4
- Intervention
- Rocuronium Bromide
- Conditions
- Muscle Relaxation
- Sponsor
- Wahba bakhet
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Quality of recovery
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Laparoscopic cholecystectomy (LC) is commonly performed on ambulatory basis as a result of its ability to improve postoperative quality of recovery (QOR) and significantly reduce hospital stay .
Detailed Description
Laparoscopic cholecystectomy (LC) is commonly performed on ambulatory basis as a result of its ability to improve postoperative quality of recovery (QOR) and significantly reduce hospital stay. The surgeon requires a good surgical conditions to perform the operation, whereas the anesthesiologist is concerned with postoperative QOR. Pneumoperitoneium -associated expansion of the abdominal cavity during LC is related to postoperative pain. and other physiological changes, affecting the postoperative QOR negatively . Poor postoperative QOR leads to prolonged hospital stay .
Investigators
Wahba bakhet
Lecturer
Ain Shams University
Eligibility Criteria
Inclusion Criteria
- •ASA I and II
Exclusion Criteria
- •Neuromuscular disorders
Arms & Interventions
Deep block
In the deep NMB-group, a PTC of 1 to 2 twitches was maintained, and NMB was reversed with sugammadex at the end of surgery.
Intervention: Rocuronium Bromide
Moderate block
In the moderate NMB group, a TOF count of 1 to 2 was maintained and NMB was reversed with a combination of neostigmine and glycopyrolate at the end of surgery.
Intervention: Rocuronium Bromide
Outcomes
Primary Outcomes
Quality of recovery
Time Frame: 24 hours postoperative
Quality of recovery-40 (QoR-40) questionnaire, which includes five general quality of life dimensions: physical independence (5 items), pain (7 items), .emotional state (9 items), psychological support (7 items), and physical independence (5 items). Each item was graded with a 5-point score: none of the time, some of the time,usually, most of the time and all of the time. The total score on the QoR- 40 questionnaire ranges from 40 to 200 representing, respectively, extremely poor to excellent
Surgical conditions
Time Frame: Intraoperative
The surgeon assessed surgical condition every 10 minutes
Secondary Outcomes
- Postoperative pain(During the length of hospital stay post surgery (on average 24 hours))