Puerarin Effects on Alcohol Drinking

Phase 2

Completed

• Conditions: Alcohol Abuse
• Interventions: Drug: Puerarin, Placebo

• Registration Number: NCT00854724
• Lead Sponsor: Mclean Hospital

Brief Summary

This research is designed to assess the impact of pretreatment with puerarin (NPI-031G), a major ingredient in the plant kudzu, on alcohol drinking. Hypothesis: Short-term treatment with this compound will reduce alcohol self-administration in a simulated natural settings laboratory.

Detailed Description

Participants will have an opportunity to drink up to 6 beers, plus water and juice, during a 90 minute afternoon drinking session in our simulated apartment room laboratory. Drinking sessions will be conducted in the afternoon after participants take puerarin or placebo for 7 days.

Study Timeline

• Study Start: 2009-02
• Study First Submitted: 2009-02-27
• Study First Submitted QC: 2009-02-27
• Study First Posted: 2009-03-03
• Primary Completion: 2011-03
• Study Completion: 2011-07
• Results First Submitted: 2011-07-19
• Results First Submitted QC: 2011-07-19
• Results First Posted: 2011-08-12
• Status Verified: 2011-09
• Last Update Submitted: 2011-09-01
• Last Update Posted: 2011-09-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• moderate to heavy alcohol drinkers (20+ drinks per week)

Exclusion Criteria

• alcohol dependence or treatment-seeking drinkers
• other drug abuse or dependence
• psychiatric disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Puerarin	Puerarin, Placebo	-
Placebo	Puerarin, Placebo	Sugar beet filler in capsule

Primary Outcome Measures

Name	Time	Method
Amount of Alcohol Consumed	During a 90 minute drinking session

Trial Locations

Locations (1)

McLean Hospital, Behavioral Psychopharmacology Research Laboratory; 🇺🇸 Belmont, Massachusetts, United States