Clinical and Radiological profile of disease of cerebrovascular system in hypertensive disease of pregnancy

Not yet recruiting

Conditions: Peripartum females with history of hypertension.

Registration Number: CTRI/2018/07/014890

Brief Summary: Hypertensive disease of pregnancy,also known as maternal hypertensive disorder is a group of diseases that include preeclampsia,eclampsia.gestational hypertension and chronic hypertension.Maternal hypertensive disorders occurred in about 20.7 million women in 2013.About 10% of pregnancies globally are complicated by hypertensive diseases.They are one of the three major causes of death in pregnancy (16%) alongwith post partum bleeding (13%) and puerperial infections(2%). A total of 50 patients will be selected after meeting the inclusion criteria. A detailed history will be taken and clinical examination will be done. Obstetric data such as parity, antenatal care, gestational age at the onset of stroke, and the presence of complications like PET , eclampsia, anemia, and sepsis will be noted. The following investigations will be carried out on all patients: complete hemogram, platelet count, Mean platelet volume, and renal functions test. Fundus examination will be done.The CT scan will be done on 128 slice Siemens perspective AS model. Three arterial sections will be taken. MRI scan will be done on Siemens Avanto system. T1W, T2W, FLAIR, and DWI/ADV and SWI axial and coronal sequences will be done with 3 mm slice thickness. MR venogram ant MR Angiography will be done if required. CT will be done for postpartum patients. MRI will be done for antepartum patients. Patients will not bear the cost of CT/MRI if it is done solely for study/research purpose. Statistical analysis All the recorded data will be noted on excel sheet and will be analysed by appropriate stastical tests.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: Female

Target Recruitment: 50

Inclusion Criteria

Peripartum females with history of hypertension.

Exclusion Criteria

1.Patients with history of any systemic illness.
2.Patients with history of any benign or malignant neoplasm involving central nervous system.
3.Patients with cardiac pacemaker or in which MRI is contraindicated.
4.Patients who are not willing to participate in the study.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
cerebral oedema	30 min \| 45min \| 60min
ischemia	30 min \| 45min \| 60min
haemorrhage	30 min \| 45min \| 60min

Secondary Outcome Measures

Name	Time	Method
cerebral venous thrombosis.	posterior reversible cerebral vasoconstriction syndrome.

Trial Locations

Locations (1): Guru Gobind Singh Medical College and Hospital,Faridkot
🇮🇳
Faridkot, PUNJAB, India
Guru Gobind Singh Medical College and Hospital,Faridkot
🇮🇳Faridkot, PUNJAB, India
DrDivya Soin
Principal investigator
7814422672
divyasoin12@gmail.com