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临床试验/CTRI/2018/07/014890
CTRI/2018/07/014890尚未招募不适用

Clinicoradiological profile of cerebrovascular disease in hypertensive disease of pregnancy.

未提供1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2018年7月16日最近更新:

试验速览

阶段
不适用
状态
尚未招募
入组人数
50
试验地点
1
主要终点
cerebral oedema

研究概览

简要总结

Hypertensive disease of pregnancy,also known as maternal hypertensive disorder is a group of diseases that include preeclampsia,eclampsia.gestational hypertension and chronic hypertension.Maternal hypertensive disorders occurred in about 20.7 million women in 2013.About 10% of pregnancies globally are complicated by hypertensive diseases.They are one of the three major causes of death in pregnancy (16%) alongwith post partum bleeding (13%) and puerperial infections(2%). A total of 50 patients will be selected after meeting the inclusion criteria. A detailed history will be taken and clinical examination will be done. Obstetric data such as parity, antenatal care, gestational age at the onset of stroke, and the presence of complications like PET , eclampsia, anemia, and sepsis will be noted. The following investigations will be carried out on all patients: complete hemogram, platelet count, Mean platelet volume, and renal functions test. Fundus examination will be done.The CT scan will be done on 128 slice Siemens perspective AS model. Three arterial sections will be taken. MRI scan will be done on Siemens Avanto system. T1W, T2W, FLAIR, and DWI/ADV and SWI axial and coronal sequences will be done with 3 mm slice thickness. MR venogram ant MR Angiography will be done if required. CT will be done for postpartum patients. MRI will be done for antepartum patients. Patients will not bear the cost of CT/MRI if it is done solely for study/research purpose. Statistical analysis All the recorded data will be noted on excel sheet and will be analysed by appropriate stastical tests.

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 50.00 Year(s)(—)
性别
Female

入选标准

  • Peripartum females with history of hypertension.

排除标准

  • 1.Patients with history of any systemic illness.
  • 2.Patients with history of any benign or malignant neoplasm involving central nervous system.
  • 3.Patients with cardiac pacemaker or in which MRI is contraindicated.
  • 4.Patients who are not willing to participate in the study.

结局指标

主要结局

cerebral oedema

时间窗: 30 min | 45min | 60min

ischemia

时间窗: 30 min | 45min | 60min

haemorrhage

时间窗: 30 min | 45min | 60min

次要结局

  • cerebral venous thrombosis.(posterior reversible cerebral vasoconstriction syndrome.)

研究者

发起方
未提供

研究点 (1)

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