Polarization Sensitive Optical coherence tomography-study

Completed

Conditions: fibrillary ocular structures
10042261

Registration Number: NL-OMON52150

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 112

Inclusion Criteria

• Patients with glaucoma, high myopia or exudative AMD
• Healthy participants
• 18 years of age or older
• Willing and able to sign the informed consent, after reading the patient
information form
• Able to maneuver into the ophthalmic devices (in case of wheelchair-bound
type III patients)
• OI patients need to be accompanied by a friend or family member during their
visit

Exclusion Criteria

• Media opacities, like cataract, causing unreliable images with the PS-OCT
• Any ocular disease (outside glaucoma/myopia/exudative AMD) with possible
influence on ocular fibrillary structures
• Recent (< 3 months) ocular surgery

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) quantification of the amount of variability in fibrosis measurements<br /><br>calculated from PS-OCT images; the standard deviation of fibrosis volume<br /><br>measurement needs to be measured within one session in several patients to<br /><br>determine the sample size and expectations of future research to measure<br /><br>fibrosis growth.<br /><br>2) A change to the scleral retinal ring layer around the optic nerve head in<br /><br>myopia and glaucoma patients when compared to nearly age/sex-matched healthy<br /><br>volunteers.<br /><br>3) Measuring the orientation of collagen in the peripapillary sclera in OI<br /><br>patients.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcome measures are:<br /><br>Current diagnostics tools (visual acuity, slit-lamp examination/biomicroscopy,<br /><br>fundusphotography, standard OCT, eye pressure, axial measurement)<br /><br>General quality metrics for PS-OCT scans by calculating feature signal-to-noise<br /><br>ratio and the useful signal penetration depth in the sclera for patients and<br /><br>healthy volunteers.</p><br>