Autologous Fibroblast Grafts in Facial Skin Regeneration
Not Applicable
- Conditions
- Skin Aging
- Interventions
- Procedure: autologous fibroblasts grafts
- Registration Number
- NCT01490554
- Lead Sponsor
- Federal University of São Paulo
- Brief Summary
The purpose of this study is to evaluate the presence of skin changes after grafting of autologous fibroblasts by means of biophysical, histological, immunohistological, gene expression, glycosaminoglycan, and sensitivity analyses.
- Detailed Description
- Analytical prospective autocontrolled study
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 20
Inclusion Criteria
- Women, aged between 50 to 70 years with facial wrinkles (rhytides),
- Fitzpatrick III skin type, and
- Who had reached menopause at least 3 years before entering the study were eligible for participation.
Exclusion Criteria
- Women with uncontrolled comorbid conditions,
- Smokers,
- Alcohol and corticosteroid users,
- Who had undergone chemical peeling or skin filling in the face or neck at least 12 months prior to the study,
- Who had a keloid scar,
- Who scored below 18 on the Mini-Mental State Examination,
- Who had any psychiatric disorder or those undergoing orthodontic treatment were excluded from the study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description autologous fibroblast grafts autologous fibroblasts grafts autologous fibroblast grafts
- Primary Outcome Measures
Name Time Method Regeneration of facial ectoderm one year after the grafting of autologous fibroblasts. To evaluate the presence of skin changes after grafting of autologous fibroblasts by means of biophysical, histological, immunohistological, gene expression, glycosaminoglycan, and sensitivity analyses.
- Secondary Outcome Measures
Name Time Method