NCT01490554Unknown不适用
Effectiveness of Autologous Fibroblast Grafts in the Regeneration of Facial Ectoderm
Federal University of São Paulo0 个研究点目标入组 20 人开始时间: 2007年3月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 主要终点
- Regeneration of facial ectoderm
研究概览
简要总结
The purpose of this study is to evaluate the presence of skin changes after grafting of autologous fibroblasts by means of biophysical, histological, immunohistological, gene expression, glycosaminoglycan, and sensitivity analyses.
详细描述
- Analytical prospective autocontrolled study
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women, aged between 50 to 70 years with facial wrinkles (rhytides),
- •Fitzpatrick III skin type, and
- •Who had reached menopause at least 3 years before entering the study were eligible for participation.
排除标准
- •Women with uncontrolled comorbid conditions,
- •Alcohol and corticosteroid users,
- •Who had undergone chemical peeling or skin filling in the face or neck at least 12 months prior to the study,
- •Who had a keloid scar,
- •Who scored below 18 on the Mini-Mental State Examination,
- •Who had any psychiatric disorder or those undergoing orthodontic treatment were excluded from the study.
结局指标
主要结局
Regeneration of facial ectoderm
时间窗: one year after the grafting of autologous fibroblasts.
To evaluate the presence of skin changes after grafting of autologous fibroblasts by means of biophysical, histological, immunohistological, gene expression, glycosaminoglycan, and sensitivity analyses.
次要结局
未报告次要终点
研究者
LYDIA MASAKO FERREIRA
Full Professor and Chairwoman and Head of the Division of Plastic Surgery and Department of Surgery, Federal University of Sao Paulo-UNIFESP, SP, Brazil
Federal University of São Paulo
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