Effectiveness of Autologous Fibroblast Grafts in the Regeneration of Facial Ectoderm
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Skin Aging
- Sponsor
- Federal University of São Paulo
- Enrollment
- 20
- Primary Endpoint
- Regeneration of facial ectoderm
- Last Updated
- 13 years ago
Overview
Brief Summary
The purpose of this study is to evaluate the presence of skin changes after grafting of autologous fibroblasts by means of biophysical, histological, immunohistological, gene expression, glycosaminoglycan, and sensitivity analyses.
Detailed Description
- Analytical prospective autocontrolled study
Investigators
LYDIA MASAKO FERREIRA
Full Professor and Chairwoman and Head of the Division of Plastic Surgery and Department of Surgery, Federal University of Sao Paulo-UNIFESP, SP, Brazil
Federal University of São Paulo
Eligibility Criteria
Inclusion Criteria
- •Women, aged between 50 to 70 years with facial wrinkles (rhytides),
- •Fitzpatrick III skin type, and
- •Who had reached menopause at least 3 years before entering the study were eligible for participation.
Exclusion Criteria
- •Women with uncontrolled comorbid conditions,
- •Alcohol and corticosteroid users,
- •Who had undergone chemical peeling or skin filling in the face or neck at least 12 months prior to the study,
- •Who had a keloid scar,
- •Who scored below 18 on the Mini-Mental State Examination,
- •Who had any psychiatric disorder or those undergoing orthodontic treatment were excluded from the study.
Outcomes
Primary Outcomes
Regeneration of facial ectoderm
Time Frame: one year after the grafting of autologous fibroblasts.
To evaluate the presence of skin changes after grafting of autologous fibroblasts by means of biophysical, histological, immunohistological, gene expression, glycosaminoglycan, and sensitivity analyses.