WISER After Ovarian Cancer - Exercise Pilot Study

Not Applicable

Completed

• Conditions: Ovarian Cancer
• Interventions: Behavioral: Exercise

• Registration Number: NCT02529150
• Lead Sponsor: Abramson Cancer Center at Penn Medicine

Brief Summary

One in four deaths in the United States is due to cancer, and one in three women will develop cancer in her lifetime. Despite improvements in survival among other forms of cancer, ovarian cancer prognosis remains poor. Eighty percent of women with ovarian cancer will present with advanced disease (stage 3 or 4) where 5-year survival ranges from 18-34%.2 Among patients with stage III and IV epithelial ovarian cancer (EOC), recurrence rates are high.4 Therefore, interventions focused on preventing recurrence or slowing progression of EOC is a critical problem in the field. The investigators have submitted an R21 to NCI for a dose response exercise intervention trial to examine the dose response effects of aerobic exercise on biomarkers relevant to ovarian cancer progression and recurrence. The reviewers would like assurance that the investigators can recruit ovarian cancer patients into an exercise study and that these women will do the exercise protocol we plan to prescribe in our high dose of exercise.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-05
• Study First Submitted: 2015-06-19
• Study First Submitted QC: 2015-08-19
• Study First Posted: 2015-08-20
• Primary Completion: 2015-12
• Study Completion: 2016-05-06
• Status Verified: 2020-04
• Last Update Submitted: 2020-04-15
• Last Update Posted: 2020-04-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 10

Inclusion Criteria

• Diagnosis of stage III-IV EOC, completed surgery,
• > 12 months life expectancy (physician estimate),
• able to walk 15 minutes at a time (use of a cane is acceptable).

Exclusion Criteria

• medical or psychiatric conditions (beyond ovarian cancer, its treatment, and its symptoms) that would impair our ability to test study hypotheses (e.g. cardiac, pulmonary, or
• orthopedic history that would prohibit a program of walking for exercise;
• psychotic disorders,
• dementia,
• inability to give informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
exercise	Exercise	-

Primary Outcome Measures

Name	Time	Method
Number of adverse events	26 weeks

Trial Locations

Locations (1)

Abramson Cancer Center of the University of Pennsylvania; 🇺🇸 Philadelphia, Pennsylvania, United States