Mean Arterial Pressure Reduction During the First Ten Minutes After General Anesthesia Induction Using Propofol Bolus or Tritiated Target-infusion: Superiority Randomized Controlled Trial
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Mean arterial pressure after 2 minutes
研究概览
简要总结
To compare haemodynamics and bispectral index values between conventional bolus propofol induction and target-controlled propofol infusion.
详细描述
To compare mean arterial pressure, heart rate and bispectral index values between conventional bolus propofol induction and target-controlled propofol infusion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
Participant and outcomes Assessor will not know group allocation.
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Scheduled for general anesthesia;
- •No contraindication for propofol.
排除标准
- •Data loss;
- •Protocol violation.
研究组 & 干预措施
Conventional bolus induction
Hypnotic component of general anesthesia induction will be a single bolus of propofol 2mg/kg followed by turning on sevoflurane 2% at a fresh gas flow of 2L/min.
干预措施: Propofol (Drug)
Target-controlled induction
Hypnotic component of general anesthesia induction will be target-controlled propofol infusion tritiated to loss of consciousness. Propofol target-controlled infusion will be maintained.
干预措施: Propofol Injection [Diprivan] (Drug)
结局指标
主要结局
Mean arterial pressure after 2 minutes
时间窗: 2 minutes after general anesthesia induction
Mean arterial pressure using non-invasive device
Mean arterial pressure after 4 minutes
时间窗: 4 minutes after general anesthesia induction minutes after general anesthesia induction
Mean arterial pressure using non-invasive device
Mean arterial pressure after 6 minutes
时间窗: 6 minutes after general anesthesia induction minutes after general anesthesia induction
Mean arterial pressure using non-invasive device
Mean arterial pressure after 8 minutes
时间窗: 8 minutes after general anesthesia induction minutes after general anesthesia induction
Mean arterial pressure using non-invasive device
Mean arterial pressure after 10 minutes
时间窗: 10 minutes after general anesthesia induction minutes after general anesthesia induction
Mean arterial pressure using non-invasive device
次要结局
- Heart Rate after 4 minutes(4 minutes after general anesthesia induction)
- Heart Rate after 6 minutes(6 minutes after general anesthesia induction)
- Heart Rate after 8 minutes(8 minutes after general anesthesia induction)
- Bispectral Index after 4 minutes(4 minutes after general anesthesia induction)
- Heart Rate after 2 minutes(2 minutes after general anesthesia induction)
- Bispectral Index after 6 minutes(6 minutes after general anesthesia induction)
- Bispectral Index after 8 minutes(8 minutes after general anesthesia induction)
- Heart Rate after 10 minutes(10 minutes after general anesthesia induction)
- Bispectral Index after 2 minutes(2 minutes after general anesthesia induction)
- Bispectral Index after 10 minutes(10 minutes after general anesthesia induction)
研究者
Gabriel Magalhaes Nunes Guimaraes
Voluntary professor
Brasilia University Hospital