Analyzing the Relationship Between Speed Propofol is Given and Low Blood Pressure

Phase 3

Completed

Brief Summary: The objective of this study is to evaluate the hemodynamic changes related to Propofol administration rate. We hypothesize that slow administration of IV propofol will have less hemodynamic disturbances and will require less amount of vasoactive medication for BP correction when compared to standard FDA approved administration rate.

Recruitment & Eligibility

Inclusion Criteria

any patient from 18 till 80 years of age
patient undergoing non-cardiac elective surgery
duration of the surgery longer than one hour
native/fluent English speaker
patients whose staff anesthesiologist planned to use Propofol as a primary anesthetic for induction

Exclusion Criteria

any patient admitted for non-elective surgery
any patient undergoing cardiac surgery
any patient under 18 years of age
any patient older than 80 years of age
any patient with history of severe heart disease (CHF with significant limitations of activity due to sever symptoms, prior heart surgery, atrial fibrillation, etc.)
any patient with pre-operative hemodynamic instability (e.g. sepsis, chronic kidney disease, liver cirrhosis) who requires constant or intermittent administration of vasoactive or inotropic medication to support vital signs (BP)
any patient on vasoactive or inotrop medications in early pre-operative period (within 24 hours prior to the surgery)
any patient who does not speak English or not fluently
any patient with cognitive impairment or mentally incapacitation
any pregnant or breastfeeding females
any patient whose staff anesthesiologist planned to use a primary anesthetic other than Propofol

Primary Outcome Measures

Name	Time	Method
Patients Administered Propofol at a Slower Rate of Infusion Will Have Lower Incidence of Post Induction Hypotension Than Patients Administered Propofol at FDA Approved Rate.	induction to 1 hour post induction	We will collect the patient's blood pressure intra-operatively every 5 minutes starting on induction up to one hour after induction and compare.

Secondary Outcome Measures

Name	Time	Method
Patients Administered Propofol at a Slower Rate Will Have Less Complications During the Early Post-op Period Than Patients Administered Propofol at FDA Approved Rate.	immediate post-op to 30 days post operatively	We will collect the patient's blood pressure post-operatively and length of hospital stay and compare.

Locations (1): The University of Toledo Medical Center
🇺🇸
Toledo, Ohio, United States
The University of Toledo Medical Center
🇺🇸Toledo, Ohio, United States