Monitoring Exhaled Propofol to Individualize General Anesthesia
- Registration Number
- NCT01191021
- Lead Sponsor
- University of California, San Francisco
- Brief Summary
This trial investigates the relationship between concentrations of the anesthetic drug propofol in exhaled breath, blood and drug effect in volunteers undergoing general anesthesia. The main goal of this study is to develop a pharmacokinetic - and dynamic model for propofol in exhaled breath.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
-
18 years of age
- Written informed consent
- Ability and willingness to give written informed consent
- American Society of Anesthesiologists (ASA) risk score I
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Exclusion Criteria
- Volunteers ASA physical status II - III
- Pregnancy
- Volunteers with history of neurological disease or stroke
- Volunteers with a history of recreational drug abuse
- Volunteers with a history of alcohol abuse
- Smokers
- Anesthesia within 6 months
- Known drug allergies
- History of adverse events during general anesthesia
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Propofol Propofol Anesthesia Volunteers will receive propofol anesthesia on the study day.
- Primary Outcome Measures
Name Time Method Exhaled propofol (parts per billion) Continuous measurement over 90 min Processed electroencephalography (Bispectral Index (0-100)): Change from baseline during anesthesia continuous over 90 min
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Anesthesia and Perioperative Care, UCSF
🇺🇸San Francisco, California, United States