Electroencephalogram Studies of Induction and Recovery From Propofol Induced General Anesthesia
Overview
- Phase
- Not Applicable
- Intervention
- Propofol
- Conditions
- Brain Activity Under Sedation
- Sponsor
- Massachusetts General Hospital
- Enrollment
- 36
- Locations
- 1
- Primary Endpoint
- EEG Power in Alpha, Slow, and Delta Bands
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The purpose of this study is to investigate how the commonly used anesthetic drug propofol works in the brain to produce loss of consciousness. While under general anesthesia your brain waves will be measured using electroencephalogram (EEG). On a separate day, the patient's brain will be imaged using magnetic resonance imaging (MRI).
Investigators
Emery Brown
Emery N. Brown, M.D., Ph.D.
Massachusetts General Hospital
Eligibility Criteria
Inclusion Criteria
- •Healthy, non-smoking male and female volunteers, ages 18-36 with normal body weight.
- •American Society of Anesthesiologists (ASA) physical status I
Exclusion Criteria
- •History of head trauma
- •Surgical aneurysm clips
- •Cardiac pacemaker
- •Prosthetic heart valve
- •Neurostimulator
- •Implanted pumps
- •Cochlear implants
- •Metal rods, plates
- •Intrauterine device
- •Hearing aid
Arms & Interventions
Active Study Arm
Subjects recruited into this study will be required to undergo a base MRI scan of the brain. On a separate day propofol will be administered with concurrent EEG while subjects respond to stimuli.
Intervention: Propofol
Outcomes
Primary Outcomes
EEG Power in Alpha, Slow, and Delta Bands
Time Frame: 11 hours
We used EEG measurements to study the dynamics of loss of consciousness, auditory processing, sensation, and memory under general anesthesia induced with propofol. The EEG data in each of the three specific aims will be analyzed using spectral methods, source localization, and event-related potentials. Through spectral analysis, EEG power (in decibels) in alpha, slow, and delta bands are measured.