Electroencephalogram Studies of Induction and Recovery From Sevoflurane-Induced General Anesthesia
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Frequencies At Which Changes in Alpha, Theta, and Slow-Delta Wave Power Were Observed From Baseline During Sevoflurane-induced General Anesthesia
研究概览
简要总结
The investigators are performing this research study to find out how and where the anesthetic drugs sevoflurane and ketamine act in the brain. Sevoflurane and ketamine are anesthetics (a drug or agent used to decrease or eliminate the feeling of pain by causing unconsciousness). The investigators will study the brain using a machine that records the brain's electrical activity, called an electroencephalogram (EEG).
详细描述
During this research study, participants will receive sevoflurane, and sevoflurane and ketamine together, at a high enough dose to induce general anesthesia (make study participants "fall asleep"). During one visit participants will receive only sevoflurane; during another visit participants will be given both sevoflurane and ketamine together. The investigators will record EEG the entire time. The investigators will also ask some questions related to pain and cognitive function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Between the ages of 18 and 50
- •Normal body weight and habitus, BMI ≤ 30
- •Non-smoker
- •American Society of Anesthesiologists (ASA) physical status classification P1
排除标准
- •Chronic health conditions
研究组 & 干预措施
EEG Dynamics
EEG data will be collected on patients receiving sevoflurane, and sevoflurane and ketamine together.
干预措施: Ketamine (Drug)
EEG Dynamics
EEG data will be collected on patients receiving sevoflurane, and sevoflurane and ketamine together.
干预措施: Sevoflurane (Drug)
结局指标
主要结局
Frequencies At Which Changes in Alpha, Theta, and Slow-Delta Wave Power Were Observed From Baseline During Sevoflurane-induced General Anesthesia
时间窗: Approximately 60 minutes
Changes in power from baseline at various EEG spectral frequencies were assessed at sevoflurane-induced loss of responsiveness. EEGs of 12 patients were analyzed to determine changes in various EEG spectral frequencies (alpha, theta, delta, etc.) from baseline. The outcome measure reflects the associated frequency (Hz) at which changes were found under sevoflurane-induced general anesthesia. These frequency values are a representation of the findings for all 12 participants.
次要结局
未报告次要终点
研究者
Oluwaseun Johnson-Akeju, MD, MMSc
Associate Professor of Anaesthesia
Massachusetts General Hospital