Do Patients Anesthetized With Propofol Have Less Pain Than Those Anesthetized With Volatile?
Overview
- Phase
- Not Applicable
- Intervention
- propofol
- Conditions
- Varicose Vein
- Sponsor
- The Cleveland Clinic
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- The primary outcome is morphine-equivalent use from the end of surgery until the first post-operative morning.
- Status
- Terminated
- Last Updated
- 9 years ago
Overview
Brief Summary
The study will test the hypothesis that patients anesthetized with propofol suffer less postoperative pain than those anesthetized with sevoflurane.
Detailed Description
Patients undergoing s stripping operation for varicose veins will be randomized to one of two groups. Group 1 patients will receive propofol anesthesia. Group 2 patients will receive sevoflurane anesthesia. Intraoperative measurements including mean-arterial pressure, heart rate, propofol infusion rate, remifentanil infusion rate, and end-tidal sevoflurane concentration will be taken at 15 minute intervals. Patients in both groups will receive Piritramid as necessary to control pain either intravenously or through patient controlled pump. VAS pain score, mean-arterial pressure, heart rate, nausea will be evaluated at 30 minute intervals during the first four postoperative hours. Piritramid dosage and vomiting will be recorded through the first postoperative morning. Patients will rate pain based on the VAS score for the period between leaving the recovery room and the first postoperative morning
Investigators
Eligibility Criteria
Inclusion Criteria
- •Participants will undergo a stripping operation for varicose veins
- •Surgery will be performed by one physician only
- •Written informed consent
Exclusion Criteria
- •Any contraindications to the proposed interventions
- •Procedures done under regional anesthesia
Arms & Interventions
1
Patients will receive propofol anesthesia during varicose vein stripping surgery.
Intervention: propofol
2
Patients will receive sevoflurane anesthesia during varicose vein stripping surgery.
Intervention: sevoflurane
Outcomes
Primary Outcomes
The primary outcome is morphine-equivalent use from the end of surgery until the first post-operative morning.
Time Frame: first post operative morning
Secondary Outcomes
- To determine the average pain score for each group during the first four hours of recovery after surgery.(30 minute intervals for first 4 hours post operatively)