Propofol Versus Volatile Anesthesia in Post Operative Pain Management

Not Applicable

Terminated

• Conditions: Varicose Vein; Postoperative Pain
• Interventions: Drug: propofol; Drug: sevoflurane

• Registration Number: NCT00712517
• Lead Sponsor: The Cleveland Clinic

Brief Summary

The study will test the hypothesis that patients anesthetized with propofol suffer less postoperative pain than those anesthetized with sevoflurane.

Detailed Description

Patients undergoing s stripping operation for varicose veins will be randomized to one of two groups. Group 1 patients will receive propofol anesthesia. Group 2 patients will receive sevoflurane anesthesia. Intraoperative measurements including mean-arterial pressure, heart rate, propofol infusion rate, remifentanil infusion rate, and end-tidal sevoflurane concentration will be taken at 15 minute intervals. Patients in both groups will receive Piritramid as necessary to control pain either intravenously or through patient controlled pump. VAS pain score, mean-arterial pressure, heart rate, nausea will be evaluated at 30 minute intervals during the first four postoperative hours. Piritramid dosage and vomiting will be recorded through the first postoperative morning. Patients will rate pain based on the VAS score for the period between leaving the recovery room and the first postoperative morning

Study Timeline

• Study First Submitted: 2008-07-07
• Study First Submitted QC: 2008-07-09
• Study First Posted: 2008-07-10
• Study Start: 2010-09
• Primary Completion: 2014-05
• Study Completion: 2014-05
• Status Verified: 2016-07
• Last Update Submitted: 2016-07-18
• Last Update Posted: 2016-07-20

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Participants will undergo a stripping operation for varicose veins
• Surgery will be performed by one physician only
• Written informed consent

Exclusion Criteria

• Any contraindications to the proposed interventions
• Procedures done under regional anesthesia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	propofol	Patients will receive propofol anesthesia during varicose vein stripping surgery.
2	sevoflurane	Patients will receive sevoflurane anesthesia during varicose vein stripping surgery.

Primary Outcome Measures

Name	Time	Method
The primary outcome is morphine-equivalent use from the end of surgery until the first post-operative morning.	first post operative morning

Secondary Outcome Measures

Name	Time	Method
To determine the average pain score for each group during the first four hours of recovery after surgery.	30 minute intervals for first 4 hours post operatively

Trial Locations

Locations (1)

Olga Plattner , MD; 🇦🇹 Vienna, Austria