Breath Gas Measurement of Propofol During Anesthesia in Patients With Endourological Procedures
Not Applicable
Completed
- Conditions
- Urological Disease
- Registration Number
- NCT01835340
- Lead Sponsor
- University of Luebeck
- Brief Summary
Propofol can be measured continuously in breath gas during anesthesia. This study compares propofol concentration in plasma and breath gas and processed electroencephalographic monitoring (bispectral index) under clinical conditions with patients and total intravenous anesthesia. Target controlled infusion technique is used to deliver adequate propofol concentration in plasma.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 22
Inclusion Criteria
• 18 years of age
- Written informed consent
- Ability and willingness to give written informed consent
- American Society of Anesthesiologists (ASA) risk score I-II
Exclusion Criteria
- Denial of the patient
- Patients ASA physical status III- IV
- Pregnancy
- Volunteers with history of neurological disease or stroke
- Volunteers with a history of recreational drug abuse
- Volunteers with a history of alcohol abuse
- Known drug allergies
- History of adverse events during general anesthesia
- Total intravenous anesthesia not practicable
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Exhaled propofol (parts per billion) Continuous measurement over 40 min during the induction of anesthesia and 30 min during recovery of anesthesia
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link propofol exhalation to central nervous system effects in endourological anesthesia?
How does breath gas propofol monitoring compare to bispectral index for anesthetic depth assessment in urological procedures?
Are there specific biomarkers that correlate with propofol plasma-breath concentration gradients during TIVA in urology patients?
What adverse events are associated with target-controlled propofol infusion in endourological surgery and how are they managed?
How does propofol's pharmacokinetic profile in breath gas measurements relate to other intravenous anesthetics in urological disease management?
Trial Locations
- Locations (1)
Dept. of Anesthesiology and Intensive Care
🇩🇪Luebeck, Schleswig-Holstein, Germany
Dept. of Anesthesiology and Intensive Care🇩🇪Luebeck, Schleswig-Holstein, Germany