Hemodynamic Changes After Anesthesia With Propofol: Study of Biomarkers
- Conditions
- Hemodynamic Responses to Propofol
- Registration Number
- NCT02442232
- Lead Sponsor
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Brief Summary
The purpose of this study is to evaluate biomarkers affecting the hemodynamic responses to propofol. Particularly, the investigators will assess the effects of polymorphisms in NOS3 and PRKCA genes on hemodynamic responses to propofol and the effects of these polymorphisms on biomarkers related to nitric oxide after propofol anesthesia. In addition, the investigators will evaluate the effects of propofol anesthesia on biomarkers related to nitric oxide in hypertensive patients chronically treated with angiotensin-converting enzyme inhibitors.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 65
- ASA I or II
- BMI lower 30 kg/m2
- Severe hypertension
- Previous stroke
- Previous infarction
- Uncontrolled respiratory, renal, hepatic and hematological diseases.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Heart rate 10 minutes Systolic blood pressure 10 minutes Diastolic blood pressure 10 minutes Plasma nitrate levels 10 minutes Mean blood pressure 10 minutes Plasma nitrite levels 10 minutes
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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