The Influence of Injection Rate on EEG Propofol Peak Effect as Measured by Bispectral Index

Not Applicable

Completed

• Conditions: Elective Surgery; Healthy

• Registration Number: NCT00290108
• Lead Sponsor: Technical University of Munich

Brief Summary

The aim of the present study was to investigate whether injection rate of propofol has an influence on its maximum effect.

Detailed Description

The clinical daily routine indicates that slowing the rate of administration of propofol can lead to a reduction of up to 50% in the dose of propofol required to achieve the onset of a clinical endpoint of anesthesia (i.e. loss of consciousness) when titrating to effect. Therefore, it has been concluded that a slow injection requires a smaller dose of propofol as the graded effect is weakened by fast injection. This conclusion contradicts pharmacologic considerations, that a fast injection would lead to a higher peak concentration and in consequence, to a higher peak effect at the effect side, the brain.

The present study was designed to measure the Electroencephalogram (EEG) peak effect of a propofol bolus (2 mg/kg) injected with different infusion rates.

Although it is known that propofol has cardiovascular effects, the influence of injection rate on these cardiovascular changes is less clear. Others found that faster injection rates of propofol caused greater reductions in blood pressure. Other similar studies have shown no difference in blood pressure for different injection rates. An additional aim of this study was therefore to investigate the influence of different injection rates on hemodynamic parameters.

Study Timeline

• Status Verified: 1998-06
• Study Start: 2003-03
• Study Completion: 2003-12
• Study First Submitted: 2006-02-09
• Study First Submitted QC: 2006-02-09
• Last Update Submitted: 2006-02-09
• Study First Posted: 2006-02-10
• Last Update Posted: 2006-02-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 99

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
maximum hypnotic effect as indicated by the minimum BIS value.

Secondary Outcome Measures

Name	Time	Method
time to loss of consciousness
time to loss of eye lash reflex
time to BISmin
BIS at LOC
BIS at LOL
BIS 30 seconds after LOC

Trial Locations

Locations (1)

Technische Universität München, Klinikum rechts der Isar, Department of Anesthesiology; 🇩🇪 Munich, Bavaria, Germany