NCT04649840已完成不适用
Estimation of Dynamics of Humoral and Cellular Immunity in COVID-19 Patients
Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus1 个研究点 分布在 1 个国家目标入组 274 人开始时间: 2020年10月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 274
- 试验地点
- 1
- 主要终点
- The dynamics of humoral and cellular immunity
研究概览
简要总结
The goal of the project: to study the dynamics of the humoral and cellular immunity in patients after pneumonia caused by the SARS-CoV-2 virus at different time intervals, in order to predict the duration of immune protection
详细描述
- to form study groups of patients (at least 60 patients in total) who have recovered from pneumonia of varying severity caused by the SARS-CoV-2 virus (at least 30 patients in each of the groups of patients who have had pneumonia in moderate and severe forms);
- to investigate the parameters of cellular immunity (the content of antigen-specific T-cells to the main viral antigens - proteins S, N, M) in patients of different groups included in the trials, in dynamics 3, 6, 9 and 12 months after the COVID-19-associated pneumonia;
- to investigate the indicators of humoral immunity (the content of IgG to the main viral antigens - proteins S, N, M) in patients of different groups included in the trials, in dynamics 3, 6, 9 and 12 months after the COVID-19-associated pneumonia.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients recovered from the COVID-19 associated pneumonia (moderate and severe) in 1-3 month interval before inclusion into the trial;
排除标准
- •drug and alcohol addiction;
- •autoimmune diseases.
结局指标
主要结局
The dynamics of humoral and cellular immunity
时间窗: 1 year
The dynamics of both humoral and cellular immunity in response to COVID-19 infection
次要结局
未报告次要终点
研究者
研究点 (1)
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