Estimation of Dynamics of Humoral and Cellular Immunity in COVID-19 Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Covid19
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
- Enrollment
- 274
- Locations
- 1
- Primary Endpoint
- The dynamics of humoral and cellular immunity
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The goal of the project: to study the dynamics of the humoral and cellular immunity in patients after pneumonia caused by the SARS-CoV-2 virus at different time intervals, in order to predict the duration of immune protection
Detailed Description
* to form study groups of patients (at least 60 patients in total) who have recovered from pneumonia of varying severity caused by the SARS-CoV-2 virus (at least 30 patients in each of the groups of patients who have had pneumonia in moderate and severe forms); * to investigate the parameters of cellular immunity (the content of antigen-specific T-cells to the main viral antigens - proteins S, N, M) in patients of different groups included in the trials, in dynamics 3, 6, 9 and 12 months after the COVID-19-associated pneumonia; * to investigate the indicators of humoral immunity (the content of IgG to the main viral antigens - proteins S, N, M) in patients of different groups included in the trials, in dynamics 3, 6, 9 and 12 months after the COVID-19-associated pneumonia.
Investigators
Eligibility Criteria
Inclusion Criteria
- •patients recovered from the COVID-19 associated pneumonia (moderate and severe) in 1-3 month interval before inclusion into the trial;
Exclusion Criteria
- •drug and alcohol addiction;
- •autoimmune diseases.
Outcomes
Primary Outcomes
The dynamics of humoral and cellular immunity
Time Frame: 1 year
The dynamics of both humoral and cellular immunity in response to COVID-19 infection