Characterisation of Cellular and Humoral Immunity in Elderly People After Immunization With a Purified, Inactivated Japanese Encephalitis Vaccine.

Medical University of Vienna0 sites60 target enrollmentNovember 2010

ConditionsHumoral and Cellular Immune Responses

Overview

Phase: Phase 4
Intervention: Not specified
Conditions: Humoral and Cellular Immune Responses
Sponsor: Medical University of Vienna
Enrollment: 60
Primary Endpoint: cellular immunity (cytokine production upon stimulation with Japanese Encephalitis (JE) Virus Antigen) 7 days after the 2. JE-vaccination
Status: Completed
Last Updated: 8 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

The aim of this project is to investigate humoral and cellular immune responses before and after immunisation with the Japanese encephalitis vaccine IXIARO in subjects above 60 years of age and 18-40 years old subjects.

Registry

clinicaltrials.gov

Start Date

November 2010

End Date

November 2013

Last Updated

8 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Medical University of Vienna

Responsible Party

Principal Investigator

Univ. Prof. Dr. Ursula Wiedermann

Univ.Prof. MD, PhD

Medical University of Vienna

Eligibility Criteria

Inclusion Criteria

•adults (18-40 years old)
•adults (≥60 years),
•both sexes
•willingness to sign written informed consent form

Exclusion Criteria

•age below 18 years or between 41-59 years old
•status post japanese encephalitis, tick born encephalitis (TBE), dengue, yellow fever or West Nile virus infection
•previous immunization against yellow fever, japanese encephalitis (dengue or WNV)
•current acute infection (body temperature above 37,9°C)