Cellular and Humoral Immunity in Elderly After Immunization With a Japanese Encephalitis Vaccine
Phase 4
Completed
- Conditions
- Humoral and Cellular Immune Responses
- Interventions
- Biological: IXIARO
- Registration Number
- NCT01398540
- Lead Sponsor
- Medical University of Vienna
- Brief Summary
The aim of this project is to investigate humoral and cellular immune responses before and after immunisation with the Japanese encephalitis vaccine IXIARO in subjects above 60 years of age and 18-40 years old subjects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- adults (18-40 years old)
- adults (≥60 years),
- both sexes
- willingness to sign written informed consent form
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Exclusion Criteria
- age below 18 years or between 41-59 years old
- status post japanese encephalitis, tick born encephalitis (TBE), dengue, yellow fever or West Nile virus infection
- previous immunization against yellow fever, japanese encephalitis (dengue or WNV)
- current acute infection (body temperature above 37,9°C)
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description elderly IXIARO subjects are at least 60 years old (with no upper age limit), receiving 2 immunisations with IXIARO young IXIARO subjects 18 to 40 years old, receiving 2 immunisations with IXIARO
- Primary Outcome Measures
Name Time Method cellular immunity (cytokine production upon stimulation with Japanese Encephalitis (JE) Virus Antigen) 7 days after the 2. JE-vaccination 7 days after the 2 JE vaccinations
- Secondary Outcome Measures
Name Time Method